Antitumour activity of Lycium chinensis polysaccharides in liver cancer rats

被引：34
作者：
Cui, BoKang [1 ,2 ]
Chen, YanFeng [2 ,3 ]
Liu, Su [4 ]
Wang, Jun [1 ,2 ]
Li, ShuHong [1 ,2 ]
Wang, QiBo [1 ,2 ]
Li, ShengPing [1 ,2 ]
Chen, MinShan [1 ,2 ]
Lin, XiaoJun [1 ,2 ]
机构：
[1] Sun Yat Sen Univ, Ctr Canc, Dept Hepatobiliary Oncol, Guangzhou 510060, Guangdong, Peoples R China
[2] State Key Lab Oncol So China, Guangzhou 510060, Guangdong, Peoples R China
[3] Sun Yat Sen Univ, Ctr Canc, Dept Head & Neck Surg, Guangzhou 510060, Guangdong, Peoples R China
[4] Guangzhou Inst Drug Control, Dept Pharmocol, Guangzhou 510160, Guangdong, Peoples R China
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2012年 / 51卷 / 03期
关键词：
HPLC; Lycium chinensis polysaccharides; VEGF; Cyclin D1; Chemical analysis; NITROSODIETHYLAMINE/PHENOBARBITAL-INDUCED HEPATOCARCINOGENESIS; VOLATILE N-NITROSAMINES; RISK-FACTORS; GLUTATHIONE PEROXIDASE; LIPID-PEROXIDATION; ASIAN MIGRANTS; BARBARUM; MORTALITY; CURCUMIN; TISSUES;
D O I：
10.1016/j.ijbiomac.2012.05.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In the present study, polysaccharides were extracted from the Lycium chinensis (LCP). Rats were divided into four groups. Two groups (Groups A) were maintained on the basal diet, whereas the remaining three groups (Groups B, C and D) had free access to the basal diet and were orally fed with LCP at 200 mg/kg b.w. for Group B, 400 mg/kg b.w. for Group C and 600 mg/kg b.w. for Group D, respectively. Following 4 weeks of this dietary regimen, hepatocarcinogenesis was initiated in all animals by a single intraperitoneal DENA (Sigma-Aldrich, St. Louis, MO, USA) injection at a dose of 200 mg/kg body weight (mixed with peanut oil). Results still showed that L. chinensis polysaccharides (LCP) increased spleen, thymus indexs, antioxidant enzymes activities and decreased oxidative injury. In addition, LCP still significantly affect VEGF and Cyclin D1 proteins expression in liver cancer rats. It can be concluded that LCP exhibited remarkable protective effects against diethylnitrosamine (DEN)-induced oxidative hepatic injury in liver cancer rats. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：314 / 318
页数：5
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