A Facile Parallel Synthesis of Trifluoroethyl-Substituted Alkynes

被引：125

作者：

Liu, Cui-Bo ^{[1
]}

Meng, Wei ^{[1
]}

Li, Feng ^{[1
]}

Wang, Shuai ^{[1
]}

Nie, Jing ^{[1
]}

Ma, Jun-An ^{[1
]}

机构：

[1] Tianjin Univ, Dept Chem, Tianjin 300072, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 25期

关键词：

alkynes; cross-coupling; diazo compounds; homogeneous catalysis; trifluoroethylation; ION CATALYZED HOMOLOGATION; CYCLOADDITION REACTIONS; MEDICINAL CHEMISTRY; DIAZOACETIC ESTERS; 2,2,2-TRIFLUORODIAZOETHANE; TRIFLUOROMETHYLATION; FLUORINATION; KETONES; ACID; PERFLUOROALKYLATION;

D O I：

10.1002/anie.201202372

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Trifluoroethylation made easy: The ease of execution of the reaction (see scheme), which runs under mild conditions and without the need for additional base or ligands, allows for the rapid parallel synthesis of a broad variety of trifluoroethylated alkynes. Both experimental and theoretical analyses indicate that the trifluoromethylcarbene could undergo concerted insertion into the C sp-H bond of the alkyne. Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6227 / 6230

页数：4

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