Evaluation of Oxidative-Antioxidative Balance in Serum of Patients With Non Acute Hepatitis Virus Type B

Oxygen free radicals play an important role in the pathogenesis of tissue damage in many pathological conditions, including liver diseases. Aim of the present study focused on the investigation the possible relationship between serum malondialdehyde level, an index of lipid peroxidation, and ceruloplasmin levels, as protective agents against lipid peroxidation, in hepatitis B virus. A group of 26 hepatitis virus type B patients enrolled in the study, while; control group consisted of 20 healthy subjects. In the present study, total proteins. malondialdehyde (mu mol/L), ceruloplasmin oxidase activity (U/L) and ceruloplasmin concentration (g/L) were measured in sera samples of patients with non acute hepatitis B virus as well as in the healthy controls. Non significant variation (p>0.05) of total serum protein and malondialdehyde levels, while, highly significant variations were found for ceruloplasmin oxidase activity (p<0.000) and ceruloplasmin concentration (p<0.001) in patients with hepatitis B virus when compared with those of healthy individuals. The results revealed a significant elevation (p<0.000) of copper level in patients with hepatitis B virus when they were compared with healthy controls group, on the other hand, non significant variations (0.784) were observed when iron levels in patients group were compared with healthy individuals group. The levels of malodialehyde and celoplasmin oxidase activity in sera of pateints as well as in healthy controls group failed to illustrate a significant statistically correlation. We can conclude that a raise in the ceruloplasmin oxide activity is not reflex to the ambulance in the oxidation - antioxidation status, but it is produced as one of the defense system's proteins against the initial viral infection.