Osmostress-induced gene expression - a model to understand how stress-activated protein kinases (SAPKs) regulate transcription

被引：56

作者：

de Nadal, Eulalia ^{[1
]}

Posas, Francesc ^{[1
]}

机构：

[1] Univ Pompeu Fabra, Dept Ciencies Expt & Salut, Cell Signaling Unit, E-08003 Barcelona, Spain

来源：

FEBS JOURNAL | 2015年 / 282卷 / 17期

基金：

欧洲研究理事会;

关键词：

gene expression; Hog1; mammals; osmostress; p38; SAPK; stress responses; yeast; CHROMATIN-REMODELING COMPLEX; MESSENGER-RNA STABILITY; CELL-CYCLE PROGRESSION; MAP KINASE; SACCHAROMYCES-CEREVISIAE; OSMOTIC-STRESS; SIGNAL-TRANSDUCTION; HISTONE DEACETYLASE; GENOMIC EXPRESSION; P38; SAPK;

D O I：

10.1111/febs.13323

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adaptation is essential for maximizing cell survival and for cell fitness in response to sudden changes in the environment. Several aspects of cell physiology change during adaptation. Major changes in gene expression are associated with cell exposure to environmental changes, and several aspects of mRNA biogenesis appear to be targeted by signaling pathways upon stress. Exhaustive reviews have been written regarding adaptation to stress and regulation of gene expression. In this review, using osmostress in yeast as a prototypical case study, we highlight those aspects of regulation of gene induction that are general to various environmental stresses as well as mechanistic aspects that are potentially conserved from yeast to mammals.

引用

页码：3275 / 3285

页数：11

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