The role of the IGF-1 Ec in myoskeletal system and osteosarcoma pathophysiology

被引：17
|
作者：
Armakolas, Nikolaos [1 ,2 ]
Armakolas, Athanasios [1 ]
Antonopoulos, Athanasios [2 ]
Dimakakos, Andreas [1 ]
Stathaki, Martha [1 ]
Koutsilieris, Michael [1 ]
机构：
[1] Univ Athens, Athens Med Sch, Physiol Lab, Athens, Greece
[2] KAT Gen Hosp, Orthopaed Clin 3, Attiki, Greece
来源：
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2016年 / 108卷
关键词：
IGF-1; Osteosarcoma; IGF-1R; Ec; Ec peptide; Bone; Muscle repair; GROWTH-FACTOR-I; MESENCHYMAL STEM-CELLS; FACTOR E PEPTIDE; SKELETAL-MUSCLE HYPERTROPHY; MGF E PEPTIDE; REFRACTORY EWING SARCOMA; LONGITUDINAL BONE-GROWTH; HORMONE-RELATED-PROTEIN; PARATHYROID-HORMONE; PROSTATE-CANCER;
D O I：
10.1016/j.critrevonc.2016.11.004
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Growth hormone (GH) regulated mainly liver-produced insulin-like growth factor 1 (IGF-1) is a key molecule in embryonic & post embryonic development that is also involved in cancer biology. Herein we review new insights of the role of igf-1 gene products and of the IGF-1Ec isoform in muscle and bone development/repair and its role in osteosarcoma pathophysiology, underlying the possible role of the Ec peptide as a future therapeutic target. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：137 / 145
页数：9
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