Differential regulation, by MK-801, of dopamine receptor gene expression in rat nigrostriatal and mesocorticolimbic systems

被引：39

作者：

Healy, DJ ^{[1
]}

MeadorWoodruff, JH ^{[1
]}

机构：

[1] UNIV MICHIGAN,DEPT PSYCHIAT,ANN ARBOR,MI 48109

来源：

BRAIN RESEARCH | 1996年 / 708卷 / 1-2期

关键词：

glutamate; N-methyl-D-aspartate (NMDA); in situ hybridization; dizocilpine; striatum; midbrain; cortex;

D O I：

10.1016/0006-8993(95)01241-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Glutamate agonists have been shown to stimulate striatal dopamine release, but less is known about dopamine-glutamate interactions at the receptor level. We treated rats with 0.3, 1.0, or 3.0 mg/kg of MK-801, an NMDA antagonist, daily for 1 week and, using in situ hybridization, measured dopamine receptor mRNA levels in cortical and subcortical structures. MK-801 caused a significant increase of D-1 and D-2 mRNA in the dorsal and ventral striatum, a significant decrease of D-3 mRNA in the nucleus accumbens, and a significant decrease of D-1 mRNA in the limbic cortex. Dopamine autoreceptor expression, reflected by D-2 mRNA in the midbrain, was increased in the ventral tegmental area, but not in the substantia nigra. Thus, MK-801 appears to differentially regulate the mesocorticolimbic and nigrostriatal dopamine systems.

引用

页码：38 / 44

页数：7

共 53 条

[1]

ARENEDA R, 1989, J NEUROCHEM, V52, P962

[2] GLUTAMATE STIMULATION OF TYROSINE-HYDROXYLASE IS MEDIATED BY NMDA RECEPTORS IN THE RAT STRIATUM [J].