Susceptibility variants for male-pattern baldness on chromosome 20p11

被引：95

作者：

Hillmer, Axel M. ^{[1
]}

Brockschmidt, Felix F. ^{[1
]}

Hanneken, Sandra ^{[2
]}

Eigelshoven, Sibylle ^{[2
]}

Steffens, Michael ^{[3
]}

Flaquer, Antonia ^{[3
]}

Herms, Stefan ^{[1
]}

Becker, Tim ^{[3
]}

Kortuem, Anne-Katrin ^{[2
]}

Nyholt, Dale R. ^{[4
]}

Zhao, Zhen Zhen ^{[4
]}

Montgomery, Grant W. ^{[4
]}

Martin, Nicholas G. ^{[4
]}

Muehleisen, Thomas W. ^{[1
]}

Alblas, Margrieta A. ^{[1
]}

Moebus, Susanne ^{[5
]}

Joeckel, Karl-Heinz ^{[5
]}

Broecker-Preuss, Martina ^{[6
]}

Erbel, Raimund ^{[7
]}

Reinartz, Roman ^{[1
]}

Betz, Regina C. ^{[8
]}

Cichon, Sven ^{[1
,8
]}

Propping, Peter ^{[8
]}

Baur, Max P. ^{[3
]}

Wienker, Thomas F. ^{[3
]}

Kruse, Roland ^{[2
]}

Noethen, Markus M. ^{[1
,8
]}

机构：

[1] Univ Bonn, Life & Brain Ctr, Dept Genom, D-53127 Bonn, Germany

[2] Univ Dusseldorf, Dept Dermatol, D-40225 Dusseldorf, Germany

[3] Univ Bonn, Inst Med Biometry Informat & Epidemiol, D-53105 Bonn, Germany

[4] Queensland Inst Med Res, Herston, Qld 4006, Australia

[5] Univ Duisburg Essen, Inst Med Bioinformat Biometry & Epidemiol, D-45122 Essen, Germany

[6] Univ Duisburg Essen, Univ Hosp Essen, Cent Lab Unit Res & Educ, Clin Endocrinol, D-45122 Essen, Germany

[7] Univ Duisburg Essen, W German Heart Ctr Essen, Clin Cardiol, D-45122 Essen, Germany

[8] Univ Bonn, Inst Human Genet, D-53111 Bonn, Germany

来源：

NATURE GENETICS | 2008年 / 40卷 / 11期

关键词：

D O I：

10.1038/ng.228

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

We carried out a genome-wide association study in 296 individuals with male-pattern baldness (androgenetic alopecia) and 347 controls. We then investigated the 30 best SNPs in an independent replication sample and found highly significant association for five SNPs on chromosome 20p11 (rs2180439 combined P = 2.7 x 10(-15)). No interaction was detected with the X-chromosomal androgen receptor locus, suggesting that the 20p11 locus has a role in a yet-to-be-identified androgen-independent pathway.

引用

页码：1279 / 1281

页数：3

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