An efficient synthesis of 5-chloro-2, 3, 4-trifluorobenzoic acid

被引：2

作者：

Yu, Shuitao ^{[1
,3
]}

Zhou, Weiyou ^{[1
,2
]}

Xia, Zhengjun ^{[1
,3
]}

Lin, Song ^{[1
,3
]}

Chen, Zaixin ^{[1
,3
]}

机构：

[1] Yabang Med Res Inst, Changzhou 213145, Peoples R China

[2] Changzhou Univ, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

[3] Jiangsu Novel Quinolone Antibacterial Drugs Engn, Changzhou 213145, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2015年 / 06期

关键词：

quinolone-3-carboxylic acids derivatives; 5-chloro-2; 3; 4-trifluorobenzoic acid;

D O I：

10.3184/174751915X14322269913981

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5-Chloro-2, 3, 4-trifluorobenzoic acid, a key intermediate for preparing quinolone-3-carboxylic acid derivatives, was synthesised from the commercially available 2, 3, 4, 5-trifluorobenzoic acid in excellent yield by a reaction sequence involving nitration, selective reduction, diazotisation and chlorination.

引用

页码：326 / 327

页数：2

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