A Retrospective Multicenter Study of Carbon Ion Radiotherapy for Locally Advanced Olfactory Neuroblastomas

被引：26

作者：

Suefuji, Hiroaki ^{[1
]}

Koto, Masashi ^{[2
]}

Demizu, Yusuke ^{[3
]}

Saitoh, Jun-Ichi ^{[4
]}

Shioyama, Yoshiyuki ^{[1
]}

Tsuji, Hiroshi ^{[2
]}

Okimoto, Tomoaki ^{[3
]}

Ohno, Tatsuya ^{[4
]}

Nemoto, Kenji ^{[5
]}

Nakano, Takashi ^{[4
]}

Kamada, Tadashi ^{[2
]}

机构：

[1] SAGA HIMAT Fdn, Ion Beam Therapy Ctr, 3049 Harakoga Machi, Tosu, Saga 8410071, Japan

[2] Natl Inst Quantum & Radiol Sci & Technol, Hosp Natl Inst Radiol Sci, Chiba, Japan

[3] Hyogo Ion Beam Med Ctr, Dept Radiol, Tatsuno, Japan

[4] Gunma Univ, Heavy Ion Med Ctr, Maebashi, Gunma, Japan

[5] Yamagata Univ, Fac Med, Dept Radiat Oncol, Yamagata, Japan

来源：

ANTICANCER RESEARCH | 2018年 / 38卷 / 03期

关键词：

Olfactory neuroblastoma; cancer of the head and neck; carbon ion radiotherapy; radiotherapy; multicenter study; ESTHESIONEUROBLASTOMA; THERAPY; IRRADIATION; EXPERIENCE; TOXICITY; OUTCOMES; SURGERY;

D O I：

10.21873/anticanres.12399

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The purpose was to evaluate efficacy and safety of carbon ion radiotherapy (C-ion RT) in patients with locally advanced olfactory neuroblastomas (ONBs). This study was a sub-analysis of the Japan Carbon-Ion Radiation Oncology Study Group Study (1402 HN, UMIN000024473). Clinical data of T4 ONBs treated with C-ion RT at four Institutions between November 2003 and December 2014 were retrospectively reviewed. Twenty-one patients underwent C-ion RT. Seven patients had T4a and 14 had T4b tumours without cervical node metastases. The median follow-up period was 39 (range=5-111) months. The 3-year overall survival and local control rates were 88.4% and 83.0%, respectively. Grade 4 late toxicity was observed in three patients, including ipsilateral optic nerve disorder (n=2) and ipsilateral retinopathy (n=1). C-Ion RT is effective and can be a curative modality for T4 ONBs. Prospective multicenter studies are warranted to confirm these findings.

引用

页码：1665 / 1670

页数：6

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