GASTRIC ACID, CALCIUM ABSORPTION, AND THEIR IMPACT ON BONE HEALTH

被引：139
作者：
Kopic, Sascha
Geibel, John P. [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Surg, New Haven, CT 06510 USA
来源：
PHYSIOLOGICAL REVIEWS | 2013年 / 93卷 / 01期
关键词：
VITAMIN-D-RECEPTOR; PARATHYROID-HORMONE RECEPTOR; PROTEIN-KINASE-C; EXTRACELLULAR CA2+-SENSING RECEPTOR; ENTEROCHROMAFFIN-LIKE CELL; EPITHELIAL CA2+ CHANNELS; PROTON PUMP INHIBITORS; MESSENGER-RNA EXPRESSION; GROUP-SPECIFIC COMPONENT; GENE-RELATED PEPTIDE;
D O I：
10.1152/physrev.00015.2012
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Kopic S, Geibel JP. Gastric Acid, Calcium Absorption, and Their Impact on Bone Health. Physiol Rev 93:189-268, 2013; doi:10.1152/physrev.00015.2012.-Calcium balance is essential for a multitude of physiological processes, ranging from cell signaling to maintenance of bone health. Adequate intestinal absorption of calcium is a major factor for maintaining systemic calcium homeostasis. Recent observations indicate that a reduction of gastric acidity may impair effective calcium uptake through the intestine. This article reviews the physiology of gastric acid secretion, intestinal calcium absorption, and their respective neuroendocrine regulation and explores the physiological basis of a potential link between these individual systems.
引用
收藏
页码：189 / 268
页数：80
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