Perturbation of the molecular clockwork in the SCN of non-obese diabetic mice prior to diabetes onset

被引：4

作者：

Ingenwerth, Marc ^{[1
]}

Reinbeck, Anna Lena ^{[2
]}

Stahr, Anna ^{[1
]}

Partke, Hans-Joachim ^{[2
,3
]}

Roden, Michael ^{[2
,3
,4
]}

Burkart, Volker ^{[2
,3
]}

von Gall, Charlotte ^{[1
]}

机构：

[1] Heinrich Heine Univ, Fac Med, Inst Anat 2, D-40225 Dusseldorf, Germany

[2] German Diabet Ctr, Inst Clin Diabetol, Dusseldorf, Germany

[3] German Ctr Diabet Res DZD, Munich, Germany

[4] Heinrich Heine Univ, Fac Med, Dept Endocrinol & Diabetol, Dusseldorf, Germany

来源：

CHRONOBIOLOGY INTERNATIONAL | 2016年 / 33卷 / 10期

关键词：

Clock genes; diabetes; master clock molecular clockwork; NOD; photoentrainment; SUPRACHIASMATIC NUCLEUS; MOUSE MODEL; PHOTIC REGULATION; GENE-EXPRESSION; FOS EXPRESSION; LIGHT; METABOLISM; COMPONENTS; OBESE; CREB;

D O I：

10.1080/07420528.2016.1218500

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Circadian disruption is associated with the development of diabetes. Non-obese diabetic (NOD) mice show abnormal diurnal profiles in energy balance and locomotor activity suggesting circadian misalignment. Therefore, we analyzed cFos and mPER1 as markers for rhythmic neuronal activity within the suprachiasmatic nucleus (SCN) of wildtype (WT) and non-diabetic (nNOD) as well as acutely diabetic NOD (dNOD) mice. cFos levels show a day/night difference in both WT and nNOD but not in dNOD. mPER1 levels did not show a day/night difference in both nNOD and dNOD. This suggests that disruption of SCN rhythmicity in NOD mice precedes the actual onset of diabetes.

引用

页码：1369 / 1375

页数：7

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