HIV-Infected Kidney Graft Recipients Managed With an Early Corticosteroid Withdrawal Protocol: Clinical Outcomes and Messenger RNA Profiles

被引:15
作者
Muthukumar, Thangamani [1 ,2 ]
Afaneh, Cheguevara [3 ]
Ding, Ruchuang [1 ]
Tsapepas, Demetra [4 ]
Lubetzky, Michelle [1 ]
Jacobs, Samantha [5 ]
Lee, John [1 ]
Sharma, Vijay [1 ,6 ]
Lee, Jun [1 ,2 ,6 ]
Dadhania, Darshana [1 ,2 ]
Hartono, Choli [1 ,2 ,6 ]
McDermott, Jennifer [4 ]
Aull, Meredith [3 ]
Leeser, David [3 ]
Kapur, Sandip [3 ]
Serur, David [1 ,2 ,6 ]
Suthanthiran, Manikkam [1 ,2 ]
机构
[1] New York Presbyterian Weill Cornell Med Ctr, Div Nephrol & Hypertens, Dept Med, New York, NY 10065 USA
[2] New York Presbyterian Weill Cornell Med Ctr, Dept Transplantat Med, New York, NY 10065 USA
[3] New York Presbyterian Weill Cornell Med Ctr, Div Transplant Surg, Dept Surg, New York, NY 10065 USA
[4] New York Presbyterian Hosp, Dept Pharm, New York, NY USA
[5] New York Presbyterian Weill Cornell Med Ctr, Dept Med, Div Infect Dis, New York, NY 10065 USA
[6] Rogosin Inst, New York, NY USA
基金
美国国家卫生研究院; 新加坡国家研究基金会;
关键词
Kidney transplantation; HIV; Gene expression; Tacrolimus; RENAL-TRANSPLANT RECIPIENTS; ACUTE CELLULAR REJECTION; LONG-TERM; ANTIRETROVIRAL THERAPY; ANTITHYMOCYTE GLOBULIN; NONINVASIVE DIAGNOSIS; ALLOGRAFT REJECTION; URINE; RISK; METAANALYSIS;
D O I
10.1097/TP.0b013e31827ac322
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Background. The outcome of HIV-infected kidney transplant recipients managed with an early corticosteroid withdrawal protocol is not known. Methods. Eleven consecutive HIV-infected patients with undetectable plasma HIV RNA and more than 200/mm(3) CD4(+) T cells underwent deceased-donor (n=8) or living-donor (n=3) kidney transplantation at our center. All were managed with an early corticosteroid withdrawal protocol; 9 of 11 received antithymocyte globulin and 2 received basiliximab induction. We analyzed patient and graft outcomes, acute rejection rate, HIV progression, BKV replication, infections, and urinary cell mRNA profiles. Results. The median (range) follow-up was 44.5 (26-73) months. The incidence of acute rejection was 9% at 1 year and the patient and allograft survival rates were 100% and 91%, respectively. Estimated glomerular filtration rate at 1 year (mean +/- SD) was 78 +/- 39 mL/min/1.73 m(2). Plasma HIV RNA was undetectable at 24 months and none had BKV replication. Six of the 11 kidney recipients developed eight infections requiring hospitalization. Urinary cell levels of mRNA for complement components and complement regulatory proteins, cell lineage-specific proteins CD3, CD4, CD8, CTLA4, Foxp3, chemokine IP-10, cytotoxic perforin and granzyme B, and BKV VP1 mRNA were not different (P>0.05) between HIV-infected patients and HIV-negative recipients (n=22) with stable graft function and normal biopsy results. Conclusion. An early steroid withdrawal regimen with antithymocyte globulin induction was associated with excellent graft and patient outcomes in HIV-infected recipients of kidney allografts. Their urinary cell mRNA profiles are indistinguishable from those of HIV-negative patients with stable graft function and normal biopsy results.
引用
收藏
页码:711 / 720
页数:10
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