Putative virulence characteristics of Stenotrophomonas maltophilia: a study on clinical isolates

被引：16

作者：

Chhibber, Sanjay ^{[1
]}

Gupta, Ankita ^{[1
]}

Sharan, Riti ^{[1
]}

Gautam, Vikas ^{[2
]}

Ray, Pallab ^{[2
]}

机构：

[1] Panjab Univ, Dept Microbiol, Chandigarh 160014, India

[2] Postgrad Inst Med Educ & Res, Dept Med Microbiol, Chandigarh 160012, India

来源：

WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY | 2008年 / 24卷 / 12期

关键词：

EPS; LPS; Hemolysin; Hemagglutination; Protease; Phospholipase C; Siderophore production;

D O I：

10.1007/s11274-008-9812-5

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Stenotrophomonas maltophilia is an important evolving pathogen, especially in patients with cystic fibrosis (CF), but its mechanism of pathogenesis is poorly understood. The purpose of this study was to investigate the presence of potential virulence determinants in five septicemic clinical isolates of S. maltophilia. When screened for EPS biosynthesis, all five strains produced colonies on two different growth media both at 30 and 37 degrees C. LPS could be extracted from all strains successfully and all were positive for both cell-free and cell-bound hemolysin production but failed to agglutinate 3% human RBCs. Variation in the ability to produce protease and phospholipase C was observed. In addition, all strains were unable to produce pyochelin but were able to produce ornibactin in the form of hydroxamate derivatives. It was also observed that all strains showed adherence to mouse tracheal epithelium.

引用

页码：2819 / 2825

页数：7

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