Vasovagal reactions after COVID-19 vaccination in Japan

被引：1

作者：

Okuyama, Mai

Morino, Saeko

Tanaka, Kaori

Nakamura-Miwa, Haruna

Takanashi, Sayaka

Arai, Satoru

Ochiai, Masaki ^{[1
]}

Ishii, Koji ^{[1
]}

Suzuki, Motoi

Oka, Akira ^{[2
]}

Morio, Tomohiro ^{[3
,4
]}

Tanaka-Taya, Keiko ^{[5
,6
]}

机构：

[1] Natl Inst Infect Dis, Ctr Surveillance Immunizat & Epidemiol Res, Tokyo, Japan

[2] Natl Inst Infect Dis, Dept Qual Assurance Radiat Safety & Informat Syst, Tokyo, Japan

[3] Saitama Childrens Med Ctr, Dept Neurol, Saitama, Japan

[4] Tokyo Med & Dent Univ TMDU, Grad Sch Med & Dent Sci, Dept Pediat & Dev Biol, Tokyo, Japan

[5] Kanagawa Prefectural Inst Publ Hlth, Kanagawa, Japan

[6] Natl Inst Infect Dis, Ctr Surveillance Immunizat & Epidemiol Res, Toyama 1-23-1,Shinjuku Ku, Tokyo 1628640, Japan

来源：

VACCINE | 2022年 / 40卷 / 41期

关键词：

COVID-19; vaccination; Vasovagal reaction; Adverse event following immunization; Adolescents; Young adults; Immunization stress-related responses;

D O I：

10.1016/j.vaccine.2022.08.056

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Coronavirus disease 2019 (COVID-19) vaccine administration started in February 2021 in Japan. As of December 2021, approximately 75% of the population aged >= 12 years had received two doses of vaccine. We conducted a study to investigate vasovagal reactions (VVR) after COVID-19 vaccination using data on adverse events following immunization. The crude reporting rate of VVR (cases/1,000,000 doses) after vaccination was 9.6 in all age groups combined, and was more frequent in the younger age groups: 28.6 and 37.2 in individuals aged 10-19 years and 20-29 years, respectively. In individuals aged 10- 29 years, the rate was similar in males and females (33.0 and 34.2, respectively, p = 0.53); but was higher after dose 1 than after dose 2 (57.4 and 8.8, respectively, p < 0.001). Based on these results, caution needs to be exercised when vaccinating adolescents and young adults, especially with dose 1 of COVID-19 vaccines.(c) 2022 The Authors. Published by Elsevier Ltd.

引用

页码：5997 / 6000

页数：4

共 4 条

[1] Ministry of Health Labour and Welfare, 2021, COMM VACC ADV REACT
[2] Sutherland A., 2008, Morbidity and Mortality Weekly Report, V57, P457
[3] World Health Organization, 2019, IMM STRESS REL RESP
[4] Legal and regulatory processes for Japan's COVID-19 immunization program Comment
Yamamoto, Norihisa
Takahashi, Yuichi
Hayashi, Shuichiro
[J]. VACCINE, 2021, 39 (43) : 6449 - 6450

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