Etiology of Crohn's disease: many roads lead to autophagy

被引：23

作者：

Lapaquette, Pierre ^{[1
,2
,3
]}

Brest, Patrick ^{[5
,6
]}

Hofman, Paul ^{[5
,6
,7
,8
]}

Darfeuille-Michaud, Arlette ^{[1
,2
,3
,4
]}

机构：

[1] Univ Auvergne, Clermont Univ, Clermont Ferrand, France

[2] INSERM, U1071, Clermont Ferrand, France

[3] INRA, USC2018, Clermont Ferrand, France

[4] Ctr Hosp Univ, Clermont Ferrand, France

[5] CNRS, UMR 7284, INSERM, IRCAN,U1081,Team 3, F-06034 Nice, France

[6] Univ Nice Sophia Antipolis, Fac Med, Nice, France

[7] Hop Louis Pasteur, Ctr Hosp Univ Nice, Biobank Unit, F-06002 Nice, France

[8] Hop Louis Pasteur, Ctr Hosp Univ Nice, Lab Pathol Clin & Expt, F-06002 Nice, France

来源：

JOURNAL OF MOLECULAR MEDICINE-JMM | 2012年 / 90卷 / 09期

关键词：

IBD; Crohn's disease; Host susceptibility; Autophagy; E; coli; MicroRNA; INFLAMMATORY-BOWEL-DISEASE; INVASIVE ESCHERICHIA-COLI; GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; ILEAL MUCOSA; E; COLI; IMPAIRED AUTOPHAGY; GENE ATG16L1; IRGM; VARIANTS;

D O I：

10.1007/s00109-012-0934-8

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Crohn's disease is a complex multifactor diseases that occur in individuals with genetic predisposition in whom environmental and microbial triggers cause a deleterious chronic immune response. Susceptibility to Crohn's disease is influenced by common variants at many loci. Genetic studies have emphasized the role of host susceptibility in inflammatory bowel disease onset with the identification of about 100 risk loci, most of which encode proteins involved in immunity, host defense against microbes, and gut homeostasis. In this review, we focus on susceptibility genes related to autophagy in the etiology of Crohn's disease (CD) and their complex interplay with the gut microbiota, as illustrated by the relationship between immunity-related GTPase family M alleles, microRNA, and xenophagy in CD predisposition.

引用

页码：987 / 996

页数：10

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