Urate transport across the apical membrane of renal proximal tubules

被引：26
|
作者：
Endou, Hitoshi [1 ,2 ]
Anzai, Naohiko [1 ]
机构：
[1] Kyorin Univ, Sch Med, Dept Pharmacol & Toxicol, Tokyo 1818611, Japan
[2] J Pharma Co Ltd, Tokyo, Japan
来源：
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2008年 / 27卷 / 6-7期
关键词：
uric acid (urate); urate transport; URAT1; SLC22A12; PDZ; transportsome;
D O I：
10.1080/15257770802136024
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Since the molecular cloning of the renal apical urate/anion exchanger URAT1 (SLC22A12), several membrane proteins relevant to urate transport have been identified. In addition, the identification of PDZ (PSD-95, DglA, and ZO-1) domain protein PDZK1 as a binding partner of URAT1, and the emerging role of PDZ scaffold for renal apical transporters have led to a new concept of renal urate transport: urate-transporting multimolecular complex, or urate transportsome, that may form an ultimate functional unit at the apical membrane of renal proximal tubules. Elucidation of urate transportsome will lead to the new drug development for hyperuricemia.
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页码：578 / 584
页数：7
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