Steric tuning of C2-symmetric chiral N-heterocyclic carbene in gold-catalyzed asymmetric cyclization of 1,6-enynes

被引：27

作者：

Yamada, Ken-ichi ^{[1
]}

Matsumoto, Yasumasa ^{[1
]}

Selim, Khalid B. ^{[2
]}

Yamamoto, Yasutomo ^{[3
]}

Tomioka, Kiyoshi ^{[3
]}

机构：

[1] Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan

[2] Mansoura Univ, Fac Pharm, Dept Organ Pharmaceut Chem, Mansoura 35516, Egypt

[3] Doshisha Womens Coll Liberal Arts, Fac Pharmaceut Sci, Kodo, Kyotanabe 6100395, Japan

来源：

TETRAHEDRON | 2012年 / 68卷 / 22期

关键词：

ENANTIOSELECTIVE INTRAMOLECULAR HYDROAMINATION; TRANSITION METAL-COMPLEXES; ALDOL REACTION; C-C; ENYNES; LIGAND; CYCLOISOMERIZATION; ALKOXYCYCLIZATION; PLATINUM; HYDROALKOXYLATION;

D O I：

10.1016/j.tet.2012.03.107

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Steric tuning of C-2-symmetric chiral N-heterocyclic carbene (NHC) was performed in Au(I)-catalyzed asymmetric cyclization of 1,6-enyne. Higher enantioselectivity was realized when chiral NHC AuCl/AgSbF6 catalysts whose N-substituent on the NHC overlays the Au-Cl bond was utilized. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：4159 / 4165

页数：7

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