The role of bone marrow-derived cells in venous thromboembolism

被引:6
作者
Campos, Joana [1 ]
Brill, Alexander [1 ,2 ]
机构
[1] Univ Birmingham, Coll Med & Dent Sci, Inst Cardiovasc Sci, Birmingham B15 2TT, W Midlands, England
[2] Sechenov First Moscow State Med Univ, Dept Pathophysiol, Sechenov Univ, Moscow, Russia
关键词
Deep vein thrombosis; Platelets; Neutrophils; Monocytes; Lymphocytes; Red blood cells; Mast cells; DEEP-VEIN THROMBOSIS; RED-BLOOD-CELLS; MEAN PLATELET VOLUME; RISK-FACTORS; MAST-CELLS; INNATE IMMUNITY; INHIBITION; ACTIVATION; RESOLUTION; DELETION;
D O I
10.1016/j.biocel.2020.105850
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Venous thrombosis is a life-threatening condition with high morbidity and mortality. Abnormal functioning of different cells in the blood is an integral part of its pathogenesis. In this review, we describe the contribution of bone marrow-derived cells to the development of this debilitating disease. We present both epidemiological and clinical data demonstrating involvement of various cell types in venous thrombosis, and discuss potential mechanisms underlying these effects. Modern concepts including recently discovered new paradigms in thrombosis, such as neutrophil extracellular traps, mast cells, and polyphosphate, are summarized.
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页数:5
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