Clinical implication of F-18 FDG PET/CT in patients with secondary hemophagocytic lymphohistiocytosis

被引:39
作者
Kim, Jahae [1 ]
Yoo, Su Woong [1 ]
Kang, Sae-Ryung [1 ]
Bom, Hee-Seung [1 ]
Song, Ho-Chun [1 ]
Min, Jung-Joon [1 ]
机构
[1] Chonnam Natl Univ, Dept Nucl Med, Med Sch & Hosp, Donggu 501757, Gwangju, South Korea
关键词
F-18; FDG; PET/CT; Histiocytosis; Hemophagocytosis; BONE-MARROW; LYMPHOMA;
D O I
10.1007/s00277-013-1906-y
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The contribution that F-18 fluoro-2-deoxyglucose positron emission tomography/computed tomography (F-18 FDG) PET/CT makes to the diagnosis of malignancy in patients with hemophagocytic lymphohistiocytosis (HLH) is still uncertain. The aim of this study was to evaluate the diagnostic performance of F-18 FDG PET/CT for the detection of underlying malignancy, to investigate the correlation between PET and laboratory parameters, and to identify prognosis-related factors in patients with secondary HLH. We enrolled 14 patients who were diagnosed with HLH and referred for F-18 FDG PET/CT to exclude malignancy. The diagnostic performance of F-18 FDG PET/CT for malignancy detection was assessed. The correlations between PET and laboratory parameters were determined. The prognostic significance of the following factors was evaluated: PET and laboratory parameters, age in years, presence of underlying malignancy, and fever and splenomegaly. Six of the 14 patients had malignancies (four with lymphoma, one with multiple myeloma, and one with colonic malignancy). Sensitivity, specificity, and diagnostic accuracy of F-18 FDG PET/CT for malignancy detection were 83, 62.5, and 71.4 %, respectively. F-18 FDG uptake in the bone marrow and spleen was positively correlated with neutrophil count and C-reactive protein. All of the PET parameters, but none of the clinical or laboratory parameters, were significantly associated with patient outcome, as determined by univariate analysis. Given the small sample size, F-18 FDG PET/CT was useful for detecting underlying malignancy, and PET parameters correlated with laboratory parameters that reflected inflammatory status. F-18 FDG PET/CT might provide prognostic information for the management of patients with secondary HLH.
引用
收藏
页码:661 / 667
页数:7
相关论文
共 22 条
[1]   Positron Emission Tomography as a Diagnostic Tool in Infection: Present Role and Future Possibilities [J].
Basu, Sandip ;
Chryssikos, Timothy ;
Moghadam-Kia, Siamak ;
Zhuang, Hongming ;
Torigian, Drew A. ;
Alavi, Abass .
SEMINARS IN NUCLEAR MEDICINE, 2009, 39 (01) :36-51
[2]   Myelofibrosis on F-18 FDG PET imaging [J].
Burrell, SC ;
Fischman, AJ .
CLINICAL NUCLEAR MEDICINE, 2005, 30 (10) :674-674
[3]   False Positivity of FDG-PET During Hemophagocytic Lymphohistiocytosis in a Child With Hodgkin Lymphoma in Remission [J].
Corapcioglu, Funda ;
Oncel, Selim ;
Berberoglu, Kezban ;
kilic, Suar Caki ;
Aydogan, Aysen ;
Dogan, Semih .
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2009, 31 (01) :74-75
[4]   PET and PET/CT using 18F-FDG in the diagnosis and management of cancer patients [J].
Endo K. ;
Oriuchi N. ;
Higuchi T. ;
Iida Y. ;
Hanaoka H. ;
Miyakubo M. ;
Ishikita T. ;
Koyama K. .
International Journal of Clinical Oncology, 2006, 11 (4) :286-296
[5]   Imaging of Inflammation by PET, Conventional Scintigraphy, and Other Imaging Techniques [J].
Gotthardt, Martin ;
Bleeker-Rovers, Chantal P. ;
Boerman, Otto C. ;
Oyen, Wim J. G. .
JOURNAL OF NUCLEAR MEDICINE, 2010, 51 (12) :1937-1949
[6]   HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis [J].
Henter, Jan-Inge ;
Horne, AnnaCarin ;
Arico, Maurizio ;
Egeler, R. Maarten ;
Filipovich, Alexandra H. ;
Imashuku, Shinsaku ;
Ladisch, Stephan ;
McClain, Ken ;
Webb, David ;
Winiarski, Jacek ;
Janka, Gritta .
PEDIATRIC BLOOD & CANCER, 2007, 48 (02) :124-131
[7]   A bone marrow F-18 FDG uptake exceeding the liver uptake may indicate bone marrow hyperactivity [J].
Inoue, Kentaro ;
Goto, Ryoi ;
Okada, Ken ;
Kinomura, Shigeo ;
Fukuda, Hiroshi .
ANNALS OF NUCLEAR MEDICINE, 2009, 23 (07) :643-649
[8]  
Iyama Satoshi, 2008, Gan To Kagaku Ryoho, V35, P1623
[9]   Familial and acquired hemophagocytic lymphohistiocytosis [J].
Janka, Gritta E. .
EUROPEAN JOURNAL OF PEDIATRICS, 2007, 166 (02) :95-109
[10]   Rate of Decline of Ferritin in Patients With Hemophagocytic Lymphohistiocytosis as a Prognostic Variable for Mortality [J].
Lin, Tiffany F. ;
Ferlic-Stark, Laura L. ;
Allen, Carl E. ;
Kozinetz, Claudia A. ;
McClain, Kenneth L. .
PEDIATRIC BLOOD & CANCER, 2011, 56 (01) :154-155