Biogenesis, trafficking and up-regulation of nicotinic ACh receptors

被引：92
作者：
Colombo, Sara Francesca [1 ,2 ]
Mazzo, Francesca [1 ,2 ]
Pistillo, Fancesco [3 ]
Gotti, Cecilia [1 ,2 ]
机构：
[1] Univ Milan, Consiglio Nazl Ric, Inst Neurosci, Milan, Italy
[2] Univ Milan, Dept Med Biotechnol & Translat Med, Milan, Italy
[3] IRCCS NEUROMED, I-86077 Pozzilli, IS, Italy
来源：
BIOCHEMICAL PHARMACOLOGY | 2013年 / 86卷 / 08期
关键词：
Nicotinic receptors; Nicotine; Receptor assembly; Receptor up-regulation; ER associated degradation; Receptor trafficking; UBIQUITIN-PROTEASOME SYSTEM; CA2+ SENSOR VILIP-1; LONG-TERM EXPOSURE; ACETYLCHOLINE-RECEPTORS; ENDOPLASMIC-RETICULUM; BINDING-SITES; RAT-BRAIN; IN-VIVO; CHOLINERGIC-RECEPTOR; SURFACE EXPRESSION;
D O I：
10.1016/j.bcp.2013.06.023
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Chronic nicotine exposure gives rise to neural adaptations that change whole cell physiology and behaviour mainly by interacting with neuronal nicotinic acetylcholine receptors (nAChRs). The major nicotine-induced neuroadaptation is the up-regulation of brain nAChRs by means of cell-delimited post-translational mechanisms. We review what is known of the processes regulating nAChR assembly, degradation and trafficking, and how nicotine-induced modulation of these processes leads to nAChR up-regulation and changes in downstream neuronal plasticity at molecular, cellular and circuit level. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码：1063 / 1073
页数：11
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