The remarkable role of emulsifier and chitosan, dextran and PEG as capping agents in the enhanced delivery of curcumin by nanoparticles in breast cancer cells
被引:47
作者:
Sampath, Malathi
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Univ Madras, Dept Inorgan Chem, Guindy Campus, Chennai 600025, Tamil Nadu, India
Anna Univ, Crystal Growth Ctr, Chennai 600025, Tamil Nadu, IndiaUniv Madras, Dept Inorgan Chem, Guindy Campus, Chennai 600025, Tamil Nadu, India
Sampath, Malathi
[1
,3
]
Pichaimani, Arunkumar
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Bharathidasan Univ, Dept Biomed Sci, Tiruchirappalli 620024, Tamil Nadu, IndiaUniv Madras, Dept Inorgan Chem, Guindy Campus, Chennai 600025, Tamil Nadu, India
Pichaimani, Arunkumar
[2
]
Kumpati, Premkumar
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Bharathidasan Univ, Dept Biomed Sci, Tiruchirappalli 620024, Tamil Nadu, IndiaUniv Madras, Dept Inorgan Chem, Guindy Campus, Chennai 600025, Tamil Nadu, India
Kumpati, Premkumar
[2
]
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Sengottuvelan, Balasubramanian
[1
]
机构:
[1] Univ Madras, Dept Inorgan Chem, Guindy Campus, Chennai 600025, Tamil Nadu, India
[2] Bharathidasan Univ, Dept Biomed Sci, Tiruchirappalli 620024, Tamil Nadu, India
[3] Anna Univ, Crystal Growth Ctr, Chennai 600025, Tamil Nadu, India
Curcumin has been found to be a powerful anti-cancer agent. However, its efficacy is limited by its poor solubility in aqueous medium. The bioavailability of curcumin was increased by poly (lactic-co-glycolic) acid [PLGA (60/40)] nanoparticles with different capping agents such as Chitosan, Dextran and PEG and emulsifier (Tocopherol Poly (Ethylene Glycol)1000 Succinate: TPGS) with good drug loading and delivery performance. The preparation of nanoparticles derived from PLGA was achieved by emulsion solvent evaporation method and the resultant nanoparticles were characterized. The encapsulation efficiency of curcumin by PLGA NPs with different capping agents such as Chitosan, PEG and Dextran and emulsifier lies in the range of 82% to 89% and the anti-oxidant activity is 80%. The in vitro anticancer activity of PLGA nanoparticles embedded with curcumin and different capping agents on MCF-7 indicates that they are more effective in arresting cell growth. The cellular uptake of TPGS emulsified dextran capped curcumin encapsulated PLGA NPs is much higher when compared to that of PLGA NPs with other capping agents, emulsifier and free curcumin. (C) 2020 Published by Elsevier B.V.
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Columbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USA
Ananthakrishnan, Preya
;
Balci, Fatih Levent
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Columbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USA
Balci, Fatih Levent
;
Crowe, Joseph P.
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Cleveland Clin Fdn, Dept Gen Surg, Cleveland, OH 44195 USAColumbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USA
机构:
The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MDThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Bisht S.
;
Feldmann G.
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机构:
The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MDThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Feldmann G.
;
Soni S.
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Department of Chemistry, University of Delhi, DelhiThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Soni S.
;
Ravi R.
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机构:
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MDThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Ravi R.
;
Karikar C.
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The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MDThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Karikar C.
;
Maitra A.
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Department of Chemistry, University of Delhi, DelhiThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Maitra A.
;
Maitra A.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemistry, University of Delhi, DelhiThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
机构:
Columbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USA
Ananthakrishnan, Preya
;
Balci, Fatih Levent
论文数: 0引用数: 0
h-index: 0
机构:
Columbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USAColumbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USA
Balci, Fatih Levent
;
Crowe, Joseph P.
论文数: 0引用数: 0
h-index: 0
机构:
Cleveland Clin Fdn, Dept Gen Surg, Cleveland, OH 44195 USAColumbia Univ Coll Phys & Surg, Dept Surg, Breast Surg Div, 630 W 168th St, New York, NY 10032 USA
机构:
The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MDThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Bisht S.
;
Feldmann G.
论文数: 0引用数: 0
h-index: 0
机构:
The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MDThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Feldmann G.
;
Soni S.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemistry, University of Delhi, DelhiThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Soni S.
;
Ravi R.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MDThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Ravi R.
;
Karikar C.
论文数: 0引用数: 0
h-index: 0
机构:
The Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MDThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Karikar C.
;
Maitra A.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemistry, University of Delhi, DelhiThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD
Maitra A.
;
Maitra A.
论文数: 0引用数: 0
h-index: 0
机构:
Department of Chemistry, University of Delhi, DelhiThe Sol Goldman Pancreatic Cancer Research Center, Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD