Local variation in the content of angiotensin II and arginine vasopressin receptor antagonistic terpenoids in the rhizomes of Alisma orientale

被引：24

作者：

Makino, B ^{[1
]}

Kobayashi, M ^{[1
]}

Kimura, K ^{[1
]}

Ishimatsu, M ^{[1
]}

Sakakibara, I ^{[1
]}

Higuchi, M ^{[1
]}

Kubo, M ^{[1
]}

Sasaki, H ^{[1
]}

Okada, M ^{[1
]}

机构：

[1] Tsumura & Co, Div Res & Dev, Kampo & Pharmacognosy Lab, Ami, Ibaraki 3001192, Japan

来源：

PLANTA MEDICA | 2002年 / 68卷 / 03期

关键词：

Alismatis rhizoma; Alisma orientale; Alismataceae; receptor binding study; antagonistic activity; HPLC;

D O I：

10.1055/s-2002-23129

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The aqueous extract of the Chinese crude drug Alismatis rhizoma, a dried rhizome of Alisma orientale Juzepczuk, exhibited in vitro inhibitory activities on angiotensin 11 and arginine vasopressin binding to their receptors. A fractionation study on the extract clarified that the known terpenoidal constituents; i.e., alisols A and B, 23-O-acetylalisol B, and alismol, were responsible for the activities. Furthermore, investigation of commercial samples of the crude drug demonstrated striking differences in their activities dependent on their locality of origin due to a difference in the amounts of these active principles. Therefore, the content of these principles could be utilized as a criteria of quality of the crude drug Alismatis rhizoma.

引用

页码：226 / 231

页数：6

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