Adverse events associated with single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews

被引:45
作者
Moore, R. Andrew [1 ]
Derry, Sheena [1 ]
Aldington, Dominic [2 ]
Wiffen, Philip J. [1 ]
机构
[1] Univ Oxford, Nuffield Div Anaesthet, Pain Res & Nuffield Dept Clin Neurosci, Oxford, England
[2] Royal Hampshire Cty Hosp, Winchester, Hants, England
来源
COCHRANE DATABASE OF SYSTEMATIC REVIEWS | 2015年 / 10期
关键词
NONSTEROIDAL ANTIINFLAMMATORY DRUGS; CLINICAL-TRIALS; NATIONAL-SURVEY; PATIENT DATA; PARACETAMOL; ACETAMINOPHEN; IBUPROFEN; METAANALYSIS; INFORMATION; MEDICATION;
D O I
10.1002/14651858.CD011407.pub2
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background This is an update of a Cochrane overview published in Issue 9, 2011; that overview considered both efficacy and adverse events. This overview considers adverse events, with efficacy dealt with in a separate overview. Thirty-nine Cochrane reviews of randomised trials have examined the adverse events associated with individual drug interventions in acute postoperative pain. This overview brings together the results of those individual reviews. Objectives To provide an overview of adverse event rates associated with single-dose oral analgesics, compared with placebo, for acute postoperative pain in adults. Methods We identified systematic reviews in The Cochrane Database of Systematic Reviews on The Cochrane Library through a simple search strategy. All reviews were overseen by a single review group. We extracted information related to participants experiencing any adverse event, and reports of serious adverse events, and deaths from the individual reviews. Main results Information was available from 39 Cochrane reviews for 41 different analgesics or analgesic combinations (51 drug/dose/formulations) tested in single oral doses in participants with moderate or severe postoperative pain. This involved around 350 unique studies involving about 35,000 participants. Most studies involved younger participants with pain following removal of molar teeth. For most nonsteroidal anti-inflammatory drugs (NSAIDs), paracetamol, and combinations not containing opioids, there were few examples where participants experienced significantly more or fewer adverse events than with placebo. For aspirin 1000 mg and diflunisal 1000 mg, opioids, or fixed-dose combination drugs containing opioids, participants typically experienced significantly more adverse events than with placebo. Studies of combinations of ibuprofen and paracetamol reported significantly fewer adverse events. Serious adverse events were rare, occurring a rate of about 1 in 3200 participants. Most reviews did not report specific adverse events. Authors' conclusions Despite ongoing problems with the measurement, recording, and reporting of adverse events in clinical trials and in systematic reviews, the large amount of information available for single oral doses of analgesics provides evidence that adverse events rates are generally similar with active drug and placebo in these circumstances, except at higher doses of some drugs, and in combinations including opioids.
引用
收藏
页数:20
相关论文
共 94 条
[1]   End-to-end military pain management [J].
Aldington, D. J. ;
McQuay, H. J. ;
Moore, R. A. .
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2011, 366 (1562) :268-275
[2]  
[Anonymous], 2000, COCHRANE DB SYST REV, DOI DOI 10.1002/14651858.CD002760
[3]   Postoperative pain experience: Results from a national survey suggest postoperative pain continues to be undermanaged [J].
Apfelbaum, JL ;
Chen, C ;
Mehta, SS ;
Gan, TJ .
ANESTHESIA AND ANALGESIA, 2003, 97 (02) :534-540
[4]   Bias from industry trial funding? A framework, a suggested approach, and a negative result [J].
Barden, J ;
Derry, S ;
McQuay, HJ ;
Moore, RA .
PAIN, 2006, 121 (03) :207-218
[5]   Single dose oral ketoprofen and dexketoprofen for acute postoperative pain in adults [J].
Barden, Jodie ;
Derry, Sheena ;
McQuay, Henry J. ;
Moore, R. Andrew .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2009, (04)
[6]   Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials [J].
Bhala, N. ;
Emberson, J. ;
Merhi, A. ;
Abramson, S. ;
Arber, N. ;
Baron, J. A. ;
Bombardier, C. ;
Cannon, C. ;
Farkouh, M. E. ;
FitzGerald, G. A. ;
Goss, P. ;
Halls, H. ;
Hawk, E. ;
Hawkey, C. ;
Hennekens, C. ;
Hochberg, M. ;
Holland, L. E. ;
Kearney, P. M. ;
Laine, L. ;
Lanas, A. ;
Lance, P. ;
Laupacis, A. ;
Oates, J. ;
Patrono, C. ;
Schnitzer, T. J. ;
Solomon, S. ;
Tugwell, P. ;
Wilson, K. ;
Wittes, J. ;
Baigent, C. ;
Adelowo, O. ;
Aisen, P. ;
Al-Quorain, A. ;
Altman, R. ;
Bakris, G. ;
Baumgartner, H. ;
Bresee, C. ;
Carducci, M. ;
Chang, D-M. ;
Chou, C-T. ;
Clegg, D. ;
Cudkowicz, M. ;
Doody, L. ;
El Miedany, Y. ;
Falandry, C. ;
Farley, J. ;
Ford, L. ;
GarciLosa, M. ;
Gonzalez-Ortiz, M. ;
Haghighi, M. .
LANCET, 2013, 382 (9894) :769-779
[7]   Mechanism of action of acetaminophen: Is there a cyclooxygenase 3? [J].
Botting, RM .
CLINICAL INFECTIOUS DISEASES, 2000, 31 :S202-S210
[8]   NATIONAL SURVEY OF HOSPITAL PATIENTS [J].
BRUSTER, S ;
JARMAN, B ;
BOSANQUET, N ;
WESTON, D ;
ERENS, R ;
DELBANCO, TL .
BRITISH MEDICAL JOURNAL, 1994, 309 (6968) :1542-1546
[9]   Single dose oral rofecoxib for acute postoperative pain in adults [J].
Bulley, Simon ;
Derry, Sheena ;
Moore, R. Andrew ;
McQuay, Henry J. .
COCHRANE DATABASE OF SYSTEMATIC REVIEWS, 2009, (04)
[10]   COX-3, a cyclooxygenase-1 variant inhibited by acetaminophen and other analgesic/antipyretic drugs: Cloning, structure, and expression [J].
Chandrasekharan, NV ;
Dai, H ;
Roos, KLT ;
Evanson, NK ;
Tomsik, J ;
Elton, TS ;
Simmons, DL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (21) :13926-13931