The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer

被引：19
|
作者：
Banys, Malgorzata [1 ,2 ]
Krawczyk, Natalia [1 ]
Fehm, Tanja [1 ]
机构：
[1] Univ Dusseldorf, Dept Obstet & Gynecol, D-40225 Dusseldorf, Germany
[2] Marien Hosp, Dept Obstet & Gynecol, D-22087 Hamburg, Germany
来源：
CANCERS | 2014年 / 6卷 / 01期
关键词：
breast cancer; bone marrow; disseminated tumor cell; circulating tumor cell; tumor cell dissemination; CIRCULATING EPITHELIAL-CELLS; BONE-MARROW; PERIPHERAL-BLOOD; HER2; STATUS; MICROMETASTATIC CELLS; PROGNOSTIC RELEVANCE; RECEPTOR EXPRESSION; SYSTEMIC THERAPY; STAGE-I; RT-PCR;
D O I：
10.3390/cancers6010143
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer.
引用
收藏
页码：143 / 152
页数：10
相关论文
共 50 条
  • [31] Comparison between circulating and disseminated tumor cells in breast cancer
    Krawczyk, N.
    Fehm, T.
    Banys, M.
    Duerr-Stoerzer, S.
    Wallwiener, D.
    Solomayer, E. F.
    EJC SUPPLEMENTS, 2008, 6 (07): : 140 - 140
  • [32] Comparison between circulating and disseminated tumor cells in breast cancer
    Solomayer, E. -F.
    Banys, M.
    Krawczyk, N.
    Duerr-Stoerzer, S.
    Wallwiener, D.
    Fehm, T.
    ONKOLOGIE, 2008, 31 : 133 - 133
  • [33] Comparison between circulating and disseminated tumor cells in breast cancer
    Fehm, T.
    Solomayer, E. F.
    Hoffmann, O.
    Becker, S.
    Wallwiener, D.
    Kimmig, R.
    Kasimir-Bauer, S.
    CANCER RESEARCH, 2009, 69 (02) : 89S - 89S
  • [34] Disseminated tumor cells in luminal breast cancer: Prognosis and treatment
    Stefanovic, S.
    Diel, I.
    Sinn, P.
    Schneeweiss, A.
    Sohn, C.
    Schuetz, F.
    Domschke, C.
    ONCOLOGY RESEARCH AND TREATMENT, 2016, 39 : 47 - 48
  • [35] Clinical relevance of circulating tumor cells in esophageal cancer
    Effenberger, Katharina E.
    Reeh, Matthias
    Riethdorf, Sabine
    Eichstaedt, Dominique
    Izbicki, Jakob R.
    Bockhorn, Maximilian
    Pantel, Klaus
    CANCER RESEARCH, 2012, 72
  • [36] Clinical relevance of circulating tumor cells in cancer patients
    Hamilton G.
    memo - Magazine of European Medical Oncology, 2015, 8 (4) : 227 - 230
  • [37] Clinical relevance of tumor invasion and proliferation factors in breast cancer
    Harbeck, N
    Graeff, H
    Hofler, H
    Janicke, F
    Schmitt, M
    GEBURTSHILFE UND FRAUENHEILKUNDE, 1998, 58 (07) : 374 - 381
  • [38] Disseminated and circulating tumor cells: Role in effective cancer management
    Lin, Henry
    Balic, Marija
    Zheng, Siyang
    Datar, Ram
    Cote, Richard J.
    CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2011, 77 (01) : 2 - 12
  • [39] Detection of cerebrospinal fluid tumor cells and its clinical relevance in leptomeningeal metastasis of breast cancer
    Jin Sun Lee
    Michelle E. Melisko
    Mark Jesus M. Magbanua
    Andrea T. Kablanian
    Janet H. Scott
    Hope S. Rugo
    John W. Park
    Breast Cancer Research and Treatment, 2015, 154 : 339 - 349
  • [40] Clinical relevance of detection of tumor cells in the bone marrow of primary breast cancer patients: A review
    Harbeck, N
    Abdulsalam, A
    Janicke, F
    ONKOLOGIE, 1997, 20 (05): : 387 - 392
12345