The Role and Clinical Relevance of Disseminated Tumor Cells in Breast Cancer

被引：19

作者：

Banys, Malgorzata ^{[1
,2
]}

Krawczyk, Natalia ^{[1
]}

Fehm, Tanja ^{[1
]}

机构：

[1] Univ Dusseldorf, Dept Obstet & Gynecol, D-40225 Dusseldorf, Germany

[2] Marien Hosp, Dept Obstet & Gynecol, D-22087 Hamburg, Germany

来源：

CANCERS | 2014年 / 6卷 / 01期

关键词：

breast cancer; bone marrow; disseminated tumor cell; circulating tumor cell; tumor cell dissemination; CIRCULATING EPITHELIAL-CELLS; BONE-MARROW; PERIPHERAL-BLOOD; HER2; STATUS; MICROMETASTATIC CELLS; PROGNOSTIC RELEVANCE; RECEPTOR EXPRESSION; SYSTEMIC THERAPY; STAGE-I; RT-PCR;

D O I：

10.3390/cancers6010143

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor cell dissemination is a common phenomenon observed in most cancers of epithelial origin. One-third of breast cancer patients present with disseminated tumor cells (DTCs) in bone marrow at time of diagnosis; these patients, as well as patients with persistent DTCs, have significantly worse clinical outcome than DTC-negative patients. Since DTC phenotype may differ from the primary tumor with regard to ER and HER2 status, reevaluation of predictive markers on DTCs may optimize treatment choices. In the present review, we report on the clinical relevance of DTC detection in breast cancer.

引用

页码：143 / 152

页数：10

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