Induced Pluripotent Stem Cell-Derived Neural Cells Survive and Mature in the Nonhuman Primate Brain

被引：112

作者：

Emborg, Marina E. ^{[1
,2
]}

Liu, Yan ^{[3
]}

Xi, Jiajie ^{[3
]}

Zhang, Xiaoqing ^{[3
]}

Yin, Yingnan ^{[3
]}

Lu, Jianfeng ^{[3
]}

Joers, Valerie ^{[1
]}

Swanson, Christine ^{[1
]}

Holden, James E. ^{[1
,2
]}

Zhang, Su-Chun ^{[3
,4
,5
]}

机构：

[1] Univ Wisconsin, Sch Med & Publ Hlth, Wisconsin Natl Primate Res Ctr, Preclin Parkinsons Res Program, Madison, WI 53705 USA

[2] Univ Wisconsin, Sch Med & Publ Hlth, Dept Med Phys, Madison, WI 53705 USA

[3] Univ Wisconsin, Sch Med & Publ Hlth, Waisman Ctr, Madison, WI 53705 USA

[4] Univ Wisconsin, Sch Med & Publ Hlth, Dept Neurosci, Madison, WI 53705 USA

[5] Univ Wisconsin, Sch Med & Publ Hlth, Dept Neurol, Madison, WI 53705 USA

来源：

CELL REPORTS | 2013年 / 3卷 / 03期

关键词：

MIDBRAIN DOPAMINE NEURONS; HUMAN ES; DIFFERENTIATION; GENERATION;

D O I：

10.1016/j.celrep.2013.02.016

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The generation of induced pluripotent stem cells (iPSCs) opens up the possibility for personalized cell therapy. Here, we show that transplanted autologous rhesus monkey iPSC-derived neural progenitors survive for up to 6 months and differentiate into neurons, astrocytes, and myelinating oligodendrocytes in the brains of MPTP-induced hemiparkinsonian rhesus monkeys with a minimal presence of inflammatory cells and reactive glia. This finding represents a significant step toward personalized regenerative therapies.

引用

页码：646 / 650

页数：5

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