Flaxseed (Linum usitatissimum L.) extract as well as (+)-secoisolariciresinol diglucoside and its mammalian derivatives are potent inhibitors of α-amylase activity

被引：43

作者：

Hano, Christophe ^{[1
]}

Renouard, Sullivan ^{[2
]}

Molinie, Roland ^{[2
]}

Corbin, Cyrielle ^{[1
]}

Barakzoy, Esmatullah ^{[1
]}

Doussot, Joel ^{[1
,3
]}

Lamblin, Frederic ^{[1
]}

Laine, Eric ^{[1
]}

机构：

[1] Antenne Sci Univ Chartres, Lab Biol Ligneux & Grandes Cultures UPRES EA 1207, Equipe Lignanes Linacees, F-28000 Chartres, France

[2] Univ Picardie Jules Verne, Fac Pharm, Lab Phytotechnol EA BioPI 3900, F-80037 Amiens, France

[3] Ecole SITI, Dept CASER, Conservatoire Natl Arts & Metiers, F-75141 Paris 03, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 10期

关键词：

alpha-Amylase; Diabetes; Enterodiol; Enterolactone; Flaxseed; alpha-Glucosidase; Secoisolariciresinol (diglucoside); SECOISOLARICIRESINOL DIGLUCOSIDE; GLUCOSIDASE;

D O I：

10.1016/j.bmcl.2013.03.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Type 2 diabetes mellitus (T2DM) is one of the common global diseases. Flaxseed is by far the richest source of the dietary lignans (i.e., secoisolariciresinol diglucoside) which have been shown to delay the development of T2DM in animal models. Herein, we propose the first evidences for a mechanism of action involving the inhibition of the pancreatic alpha-amylase (EC 3.2.1.1) by flaxseed-derived lignans that could therefore constitute a promising nutraceutical for the prevention and the treatment of T2DM. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：3007 / 3012

页数：6

共 26 条

[1] Inhibitory Activity of Cinnamon Bark Species and their Combination Effect with Acarbose against Intestinal α-glucosidase and Pancreatic α-amylase [J].