XPC 939A>C and 499C>T Polymorphisms and Skin Cancer Risk: a Meta-analysis

被引：6
作者：
Ji, Geng [1 ]
Lin, Yuan [2 ,3 ]
Cao, Song-Yu [2 ,3 ]
Li, Luo-Zhu [1 ]
Chen, Xin-Long [1 ]
Sun, Bu-Mei [1 ]
Chen, Chuan-Jun [1 ]
Ma, Hong-Xia [2 ,3 ]
机构：
[1] Taizhou Peoples Hosp, Dept Burns & Plast Surg, Taizhou, Peoples R China
[2] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Nanjing, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Sch Publ Hlth, Minist Educ, Key Lab Modern Toxicol, Nanjing, Jiangsu, Peoples R China
来源：
ASIAN PACIFIC JOURNAL OF CANCER PREVENTION | 2012年 / 13卷 / 10期
关键词：
XPC; polymorphism; skin cancer; meta-analysis; DNA-REPAIR GENES; PIGMENTOSUM GROUP-C; SINGLE-NUCLEOTIDE POLYMORPHISMS; BASAL-CELL CARCINOMA; XERODERMA-PIGMENTOSUM; CUTANEOUS MELANOMA; ASSOCIATION; VARIANTS; COMPLEX; DESIGN;
D O I：
10.7314/APJCP.2012.13.10.4983
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The xeroderma pigmentosum complementation group C gene (XPC) has been identified as important for repairing UV-related DNA damage. Some subtle changes in this gene may impair repair efficiency and influence susceptibility to human cancers, including skin cancer. Two polymorphisms in XPC, 939A>C (rs2228001) and 499C>T (rs2228000), are considered to have possible associations with the risk of skin cancer, but the reported results have been inconsistent. Here we performed a meta-analysis of the available evidence regarding the relationship between these two polymorphisms and the risk of skin cancer. All relevant studies were searched using PubMed, Embase and Web of Science before February 2012. A total of 8 case-control studies were included in this analysis, and no convincing associations between the two polymorphisms and risk of skin cancer were observed in any of the genetic models. Stratified analyses by skin cancer type also did not detect significant associations in any subgroup. This meta-analysis suggested that the XPC 939A>C and 499C>T polymorphisms may have little involvement in susceptibility to skin cancer.
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页码：4983 / 4988
页数：6
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