Biomarker-Calibrated Protein Intake and Physical Function in the Women's Health Initiative

被引：97

作者：

Beasley, Jeannette M. ^{[1
]}

Wertheim, Betsy C. ^{[2
]}

LaCroix, Andrea Z. ^{[3
]}

Prentice, Ross L. ^{[3
]}

Neuhouser, Marian L. ^{[3
]}

Tinker, Lesley F. ^{[3
]}

Kritchevsky, Stephen ^{[4
]}

Shikany, James M. ^{[5
]}

Eaton, Charles ^{[6
]}

Chen, Zhao ^{[7
]}

Thomson, Cynthia A. ^{[2
,7
]}

机构：

[1] Albert Einstein Coll Med, Bronx, NY 10467 USA

[2] Univ Arizona, Ctr Canc, Tucson, AZ USA

[3] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[4] Wake Forest Sch Med, Winston Salem, NC USA

[5] Univ Alabama Birmingham, Sch Med, Birmingham, AL USA

[6] Brown Univ, Mem Hosp Rhode Isl, Pawtucket, RI 02860 USA

[7] Univ Arizona, Mel & Enid Zuckerman Coll Publ Hlth, Tucson, AZ USA

来源：

JOURNAL OF THE AMERICAN GERIATRICS SOCIETY | 2013年 / 61卷 / 11期

基金：

美国国家卫生研究院;

关键词：

dietary protein intake; physical performance; physical function; grip strength; LOWER-EXTREMITY FUNCTION; FRAIL ELDERLY-PEOPLE; DIETARY-PROTEIN; OLDER-ADULTS; MUSCLE MASS; ANABOLIC RESPONSE; MEANINGFUL CHANGE; DOUBLE-BLIND; PERFORMANCE; EXERCISE;

D O I：

10.1111/jgs.12503

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

ObjectivesTo determine whether preservation of physical function with aging may be partially met through modification in dietary protein intake. DesignProspective cohort study. SettingWomen's Health Initiative (WHI) Clinical Trials (CT) and Observational Study (OS) conducted at 40 clinical centers. ParticipantsWomen aged 50 to 79 (N=134,961) with dietary data and one or more physical function measures. MeasurementsPhysical function was assessed using the short-form RAND-36 at baseline and annually beginning in 2005 for all WHI participants and at closeout for CT participants (average similar to 7years after baseline). In a subset of 5,346 participants, physical performance measures (grip strength, number of chair stands in 15seconds, and timed 6-m walk) were assessed at baseline and Years 1, 3, and 6. Calibrated energy and protein intake were derived from regression equations using baseline food frequency questionnaire data collected on the entire cohort and doubly labeled water and 24-hour urinary nitrogen collected from a representative sample as reference measures. Associations between calibrated protein intake and each of the physical function measures were assessed using generalized estimating equations. ResultsCalibrated protein intake ranged from 6.6% to 22.3% energy. Higher calibrated protein intake at baseline was associated with higher self-reported physical function (quintile (Q)5, 85.6, 95% confidence interval (CI)=81.9-87.5; Q1, 75.4, 95% CI=73.2-78.5, P-trend= .002) and a slower rate of functional decline (annualized change: Q5, -0.47, 95% CI=-0.63 to -0.39; Q1, -0.98, 95% CI=-1.18 to -0.75, P-trend=.02). Women with higher calibrated protein intake also had greater grip strength at baseline (Q5, 24.7kg, 95% CI=24.3-25.2kg; Q1, 24.1kg, 95% CI=23.6-24.5kg, P-trend=.04) and slower declines in grip strength (annualized change: Q5, -0.45kg, 95% CI=-0.39 to -0.63kg; Q1, -0.59kg, 95% CI=-0.50 to -0.66kg, P-trend=.03). Women with higher calibrated protein intake also completed more chair stands at baseline (Q5, 7.11, 95% CI=6.91-7.26; Q1, 6.61, 95% CI=6.46-6.76, P-trend=.002). ConclusionHigher calibrated protein intake is associated with better physical function and performance and slower rates of decline in postmenopausal women.

引用

页码：1863 / 1871

页数：9

共 35 条

[1]

Anderson G, 1998, CONTROL CLIN TRIALS, V19, P61

[2] Implementation of the Women's Health Initiative Study Design [J].