Synthesis, Characterization, and Self-Assembly of Poly(N-vinylpyrrolidone)-block-poly(vinyl acetate)

被引：19

作者：

Bailly, Nathalie ^{[1
]}

Pound-Lana, Gwenaelle ^{[1
]}

Klumperman, Bert ^{[1
]}

机构：

[1] Univ Stellenbosch, Dept Chem & Polymer Sci, ZA-7602 Matieland, South Africa

来源：

AUSTRALIAN JOURNAL OF CHEMISTRY | 2012年 / 65卷 / 08期

基金：

新加坡国家研究基金会;

关键词：

AMPHIPHILIC BLOCK-COPOLYMERS; MEDIATED RADICAL POLYMERIZATION; VINYL-ACETATE; RAFT POLYMERIZATION; N-VINYLPYRROLIDONE; CREMOPHOR-FREE; MICELLES; DRUG; MICELLIZATION; NANOPARTICLES;

D O I：

10.1071/CH12185

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Poly(N-vinylpyrrolidone)-block-poly(vinyl acetate) (PVP-b-PVAc) block copolymers of varying molar mass and hydrophobic block lengths were synthesized by xanthate-mediated radical polymerization. In order to control the molar mass of the hydrophilic PVP block, a xanthate chain transfer agent, S-(2-cyano-2-propyl) O-ethyl xanthate, was used. The PVP-b-PVAc block copolymer is composed of a hydrophilic and hydrophobic segment, and has the ability to self-assemble in aqueous solution. The PVP-b-PVAc block copolymers were characterized by H-1 NMR spectroscopy to confirm their self-assembly in water. The critical micelle concentration was determined by fluorescence spectroscopy. A combination of dynamic light scattering, transmission electron microscopy, and static light scattering was used to further characterize the self-assembly of the block copolymers in water.

引用

页码：1124 / 1131

页数：8

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