Cyclodextrin Anchoring on Magnetic Fe3O4 Nanoparticles Modified with Phosphonic Linkers

被引：52
作者：
Tudisco, Cristina [1 ,2 ]
Oliveri, Valentina [1 ,2 ]
Cantarella, Maria [1 ,2 ]
Vecchio, Graziella [1 ,2 ]
Condorelli, Guglielmo G. [1 ,2 ]
机构：
[1] Univ Catania, Dipartimento Sci Chim, I-95125 Catania, Italy
[2] INSTM UdR Catania, I-95125 Catania, Italy
来源：
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY | 2012年 / 32期
关键词：
Nanoparticles; Magnetite; Cyclodextrins; Drug delivery; Medicinal chemistry; Photoelectron spectroscopy; IRON-OXIDE NANOPARTICLES; SELF-ASSEMBLED MONOLAYERS; RAY PHOTOELECTRON-SPECTROSCOPY; BETA-CYCLODEXTRIN; ALUMINUM SURFACES; IN-VITRO; ACIDS; CAPTURE; FUNCTIONALIZATION; STABILIZATION;
D O I：
10.1002/ejic.201200510
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
Magnetic Fe3O4 nanoparticles (MNPs) have been covalently modified with beta-cyclodextrin (beta-CD) cavities by adopting a two-step anchoring route based on particle prefunctionalization with a phosphonic monolayer, which acts as a covalent linker between the MNPs and beta-CD. Particular attention has been devoted to the study of the functionalization process by adopting bifunctional phosphonic linkers to investigate the efficiency of the anchoring group (phosphonic acid or ester) and the role of a second functional group. The grafting process of the phosphonic linkers has been monitored by using X-ray photoelectron and FTIR spectroscopy. beta-CD has then been successfully anchored on MNPs prefunctionalized with (3-aminopropyl)phosphonic acid. The ability of beta-CD-functionalized nanoparticles to carry and slowly release some drugs has been tested by adopting the anti-inflammatory drug diclofenac sodium salt as a model.
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页码：5323 / 5331
页数：9
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