Morphology, wettability, and mechanical properties of polycaprolactone/hydroxyapatite composite scaffolds with interconnected pore structures fabricated by a mini-deposition system

被引：54

作者：

Jiang, Wenbo ^{[1
,2
]}

Shi, Jun ^{[3
]}

Li, Wei ^{[1
,2
]}

Sun, Kang ^{[1
,2
]}

机构：

[1] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, Inst Biomed Mat, Sch Mat Sci & Engn, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Dept Oral & Maxillofacial Surg, Shanghai Peoples Hosp 9, Shanghai 200011, Peoples R China

来源：

POLYMER ENGINEERING AND SCIENCE | 2012年 / 52卷 / 11期

基金：

美国国家科学基金会;

关键词：

EPSILON-CAPROLACTONE; POROUS SCAFFOLDS; BONE; POLYMER; HYDROXYAPATITE; CARTILAGE; STRENGTH; IMPLANTS; POROSITY; DEFECTS;

D O I：

10.1002/pen.23193

中图分类号：

TQ [化学工业];

学科分类号：

0817 ;

摘要：

A new mini-deposition system (MDS) was developed to fabricate scaffolds with interconnected pore structures and anatomical geometry for bone tissue engineering. Polycaprolactone/hydroxyapatite (PCL/HA) composites with varying hydroxyapatite (HA) content were adopted to manufacture scaffolds by using MDS with a porosity of 54.6%, a pore size of 716 mu m in the x-y plane, and 116 mu m in the z direction. The water uptake ratio and compressive modulus of PCL/HA composite scaffold increase from 8 to 39% and from 26.5 to 49.8 MPa, respectively, as the HA content increases from 0 to 40%. PCL/HA composite scaffolds have better wettability and mechanical properties than pure PCL scaffold. A PCL/HA composite scaffold for mandible bone repair was successfully fabricated with both interconnected pore structures and anatomical shape to demonstrate the versatility of MDS. POLYM. ENG. SCI., 2012. (C) 2012 Society of Plastics Engineers

引用

页码：2396 / 2402

页数：7

共 34 条

[1] The effect of elastin on chondrocyte adhesion and proliferation on poly (ε-caprolactone)/elastin composites [J].

Annabi, Nasim ;

Fathi, Ali ;

Mithieux, Suzanne M. ;

Martens, Penny ;

Weiss, Anthony S. ;

Dehghani, Fariba .

BIOMATERIALS, 2011, 32 (06) :1517-1525

[2] Scaffolds of poly (ε-caprolactone) with whiskers of hydroxyapatite [J].

Cardoso, G. B. C. ;

Ramos, S. L. F. ;

Rodas, A. C. D. ;

Higa, O. Z. ;

Zavaglia, C. A. C. ;

Arruda, A. C. F. .

JOURNAL OF MATERIALS SCIENCE, 2010, 45 (18) :4990-4993

[3] Synthesis of poly(ε-caprolactone)/hydroxyapatite nanocomposites using in-situ co-precipitation [J].

Choi, Won-Young ;

Kim, Hyoun-Ee ;

Oh, Se-Yoon ;

Koh, Young-Hag .

MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2010, 30 (05) :777-780

[4] 3D printing of hydroxyapatite: Effect of binder concentration in pre-coated particle on part strength [J].

Chumnanklang, R. ;

Panyathanmaporn, T. ;

Sitthiseripratip, K. ;

Suwanprateeb, J. .

MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS, 2007, 27 (04) :914-921

[5]

Diwakar K. M., 2008, EUR J SCI RES, V22, P6

[6] Selective laser sintering of hydroxyapatite/poly-ε-caprolactone scaffolds [J].

Eosoly, Szilvia ;

Brabazon, Dermot ;

Lohfeld, Stefan ;

Looney, Lisa .

ACTA BIOMATERIALIA, 2010, 6 (07) :2511-2517

[7] Tissue engineering - Current challenges and expanding opportunities [J].

Griffith, LG ;

Naughton, G .

SCIENCE, 2002, 295 (5557) :1009-+

[8] An electrospun polycaprolactone-collagen membrane for the resurfacing of cartilage defects [J].

Ho, Saey Tuan Barnabas ;

Ekaputra, Andrew Krishna ;

Hui, James Hoi ;

Hutmacher, Dietmar Werner .

POLYMER INTERNATIONAL, 2010, 59 (06) :808-817

[9]

Hutmacher DW, 2001, J BIOMED MATER RES, V55, P203, DOI 10.1002/1097-4636(200105)55:2<203::AID-JBM1007>3.3.CO

[10]

2-Z

← 1 2 3 4 →