PPARγ:: a nuclear regulator of metabolism, differentiation, and cell growth

被引:1049
作者
Rosen, ED
Spiegelman, BM [1 ]
机构
[1] Dana Farber Canc Inst, Dept Canc Biol, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA
[3] Harvard Univ, Sch Med, Dept Cell Biol, Boston, MA 02115 USA
关键词
D O I
10.1074/jbc.R100034200
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:37731 / 37734
页数:4
相关论文
共 72 条
[1]   Differential effects of rexinoids and thiazolidinediones on metabolic gene expression in diabetic rodents [J].
Ahuja, HS ;
Liu, S ;
Crombie, DL ;
Boehm, M ;
Leibowitz, MD ;
Heyman, RA ;
Depre, C ;
Nagy, L ;
Tontonoz, P ;
Davies, PJA .
MOLECULAR PHARMACOLOGY, 2001, 59 (04) :765-773
[2]   The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes [J].
Altshuler, D ;
Hirschhorn, JN ;
Klannemark, M ;
Lindgren, CM ;
Vohl, MC ;
Nemesh, J ;
Lane, CR ;
Schaffner, SF ;
Bolk, S ;
Brewer, C ;
Tuomi, T ;
Gaudet, D ;
Hudson, TJ ;
Daly, M ;
Groop, L ;
Lander, ES .
NATURE GENETICS, 2000, 26 (01) :76-80
[3]   PPARγ is required for placental, cardiac, and adipose tissue development [J].
Barak, Y ;
Nelson, MC ;
Ong, ES ;
Jones, YZ ;
Ruiz-Lozano, P ;
Chien, KR ;
Koder, A ;
Evans, RM .
MOLECULAR CELL, 1999, 4 (04) :585-595
[4]   Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension [J].
Barroso, I ;
Gurnell, M ;
Crowley, VEF ;
Agostini, M ;
Schwabe, JW ;
Soos, MA ;
Maslen, GL ;
Williams, TDM ;
Lewis, H ;
Schafer, AJ ;
Chatterjee, VKK ;
O'Rahilly, S .
NATURE, 1999, 402 (6764) :880-883
[5]   The adipocyte-secreted protein Acrp30 enhances hepatic insulin action [J].
Berg, AH ;
Combs, TP ;
Du, XL ;
Brownlee, M ;
Scherer, PE .
NATURE MEDICINE, 2001, 7 (08) :947-953
[6]   A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat [J].
Brown, KK ;
Henke, BR ;
Blanchard, SG ;
Cobb, JE ;
Mook, R ;
Kaldor, I ;
Kliewer, SA ;
Lehmann, JM ;
Lenhard, JM ;
Harrington, WW ;
Novak, PJ ;
Faison, W ;
Binz, JG ;
Hashim, MA ;
Oliver, WO ;
Brown, HR ;
Parks, DJ ;
Plunket, KD ;
Tong, WQ ;
Menius, JA ;
Adkison, K ;
Noble, SA ;
Willson, TM .
DIABETES, 1999, 48 (07) :1415-1424
[7]   Troglitazone action is independent of adipose tissue [J].
Burant, CF ;
Sreenan, S ;
Hirano, KI ;
Tai, TAC ;
Lohmiller, J ;
Lukens, J ;
Davidson, NO ;
Ross, S ;
Graves, RA .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (11) :2900-2908
[8]   An adipogenic cofactor bound by the differentiation domain of PPARγ [J].
Castillo, G ;
Brun, RP ;
Rosenfield, JK ;
Hauser, S ;
Park, CW ;
Troy, AE ;
Wright, ME ;
Spiegelman, BM .
EMBO JOURNAL, 1999, 18 (13) :3676-3687
[9]   Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones [J].
Chao, L ;
Marcus-Samuels, B ;
Mason, MM ;
Moitra, J ;
Vinson, C ;
Arioglu, E ;
Gavrilova, O ;
Reitman, ML .
JOURNAL OF CLINICAL INVESTIGATION, 2000, 106 (10) :1221-1228
[10]   A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis [J].
Chawla, A ;
Boisvert, WA ;
Lee, CH ;
Laffitte, BA ;
Barak, Y ;
Joseph, SB ;
Liao, D ;
Nagy, L ;
Edwards, PA ;
Curtiss, LK ;
Evans, RM ;
Tontonoz, P .
MOLECULAR CELL, 2001, 7 (01) :161-171