Use of adenovirus type-5 vectored vaccines: a cautionary tale

被引：44

作者：

Buchbinder, Susan P. ^{[1
,2
,3
]}

McElrath, M. Juliana ^{[4
,5
]}

Dieffenbach, Carl ^{[6
]}

Corey, Lawrence ^{[4
,5
]}

机构：

[1] San Francisco Dept Publ Hlth, Bridge HIV, San Francisco, CA 94102 USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Epidemiol, San Francisco, CA 94143 USA

[4] Fred Hutchinson Canc Res Inst, Seattle, WA USA

[5] Univ Washington, Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98195 USA

[6] NIAID, Div Aids, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

来源：

LANCET | 2020年 / 396卷 / 10260期

关键词：

HIV-1; VACCINE; DOUBLE-BLIND; EFFICACY; TRIAL; STEP; REPLICATION; ACTIVATION; IMMUNITY; AD5;

D O I：

10.1016/S0140-6736(20)32156-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E68 / E69

页数：2

共 13 条

[1] Distinct susceptibility of HIV vaccine vector-induced CD4 T cells to HIV infection [J].

Auclair, Sarah ;

Liu, Fengliang ;

Niu, Qingli ;

Hou, Wei ;

Churchyard, Gavin ;

Morgan, Cecilia ;

Frahm, Nicole ;

Nitayaphan, Sorachai ;

Pitisuthithum, Punnee ;

Rerks-Ngarm, Supachai ;

Kimata, Jason T. ;

Soong, Lynn ;

Franchini, Genoveffa ;

Robb, Merlin ;

Kim, Jerome ;

Michael, Nelson ;

Hu, Haitao .

PLOS PATHOGENS, 2018, 14 (02)

[2] Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial [J].

Buchbinder, Susan P. ;

Mehrotra, Devon V. ;

Duerr, Ann ;

Fitzgerald, Daniel W. ;

Mogg, Robin ;

Li, David ;

Gilbert, Peter B. ;

Lama, Javier R. ;

Marmor, Michael ;

del Rio, Carlos ;

McElrath, M. Juliana ;

Casimiro, Danilo R. ;

Gottesdiener, Keith M. ;

Chodakewitz, Jeffrey A. ;

Corey, Lawrence ;

Robertson, Michael N. .

LANCET, 2008, 372 (9653) :1881-1893

[3] Extended Follow-up Confirms Early Vaccine-Enhanced Risk of HIV Acquisition and Demonstrates Waning Effect Over Time Among Participants in a Randomized Trial of Recombinant Adenovirus HIV Vaccine (Step Study) [J].

Duerr, Ann ;

Huang, Yunda ;

Buchbinder, Susan ;

Coombs, Robert W. ;

Sanchez, Jorge ;

del Rio, Carlos ;

Casapia, Martin ;

Santiago, Steven ;

Gilbert, Peter ;

Corey, Lawrence ;

Robertson, Michael N. .

JOURNAL OF INFECTIOUS DISEASES, 2012, 206 (02) :258-266

[4] Immune Activation with HIV Vaccines [J].

Fauci, Anthony S. ;

Marovich, Mary A. ;

Dieffenbach, Carl W. ;

Hunter, Eric ;

Buchbinder, Susan P. .

SCIENCE, 2014, 344 (6179) :49-51

[5] Human adenovirus-specific T cells modulate HIV-specific T cell responses to an Ad5-vectored HIV-1 vaccine [J].

Frahm, Nicole ;

DeCamp, Allan C. ;

Friedrich, David P. ;

Carter, Donald K. ;

Defawe, Olivier D. ;

Kublin, James G. ;

Casimiro, Danilo R. ;

Duerr, Ann ;

Robertson, Michael N. ;

Buchbinder, Susan P. ;

Huang, Yunda ;

Spies, Gregory A. ;

De Rosa, Stephen C. ;

McElrath, M. Juliana .

JOURNAL OF CLINICAL INVESTIGATION, 2012, 122 (01) :359-367

[6] Safety and efficacy of the HVTN 503/Phambili Study of a clade-B-based HIV-1 vaccine in South Africa: a double-blind, randomised, placebo-controlled test-of-concept phase 2h study [J].

Gray, Glenda E. ;

Allen, Mai ;

Moodie, Zoe ;

Churchyard, Gavin ;

Bekker, Linda-Gail ;

Nchabeleng, Maphoshane ;

Mlisana, Koleka ;

Metch, Barbara ;

de Bruyn, Guy ;

Latka, Mary H. ;

Roux, Surita ;

Mathebula, Matsontso ;

Naicker, Nivashnee ;

Ducar, Constance ;

Carter, Donald K. ;

Puren, Adrien ;

Eaton, Niles ;

McElrath, M. Julie ;

Robertson, Michael ;

Corey, Lawrence ;

Kublin, James G. .

LANCET INFECTIOUS DISEASES, 2011, 11 (07) :507-515

[7] Efficacy Trial of a DNA/rAd5 HIV-1 Preventive Vaccine [J].

Hammer, Scott M. ;

Sobieszczyk, Magdalena E. ;

Janes, Holly ;

Karuna, Shelly T. ;

Mulligan, Mark J. ;

Grove, Doug ;

Koblin, Beryl A. ;

Buchbinder, Susan P. ;

Keefer, Michael C. ;

Tomaras, Georgia D. ;

Frahm, Nicole ;

Hural, John ;

Anude, Chuka ;

Graham, Barney S. ;

Enama, Mary E. ;

Adams, Elizabeth ;

DeJesus, Edwin ;

Novak, Richard M. ;

Frank, Ian ;

Bentley, Carter ;

Ramirez, Shelly ;

Fu, Rong ;

Koup, Richard A. ;

Mascola, John R. ;

Nabel, Gary J. ;

Montefiori, David C. ;

Kublin, James ;

McElrath, M. Juliana ;

Corey, Lawrence ;

Gilbert, Peter B. .

NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (22) :2083-2092

[8] The Inner Foreskin of Healthy Males at Risk of HIV Infection Harbors Epithelial CD4+CCR5+Cells and Has Features of an Inflamed Epidermal Barrier [J].

Lemos, Maria P. ;

Lama, Javier R. ;

Karuna, Shelly T. ;

Fong, Youyi ;

Montano, Silvia M. ;

Ganoza, Carmela ;

Gottardo, Raphael ;

Sanchez, Jorge ;

McElrath, M. Juliana .

PLOS ONE, 2014, 9 (09)

[9] HIV-1 vaccine-induced immunity in the test-of-concept Step Study: a case-cohort analysis [J].

McElrath, M. Juliana ;

De Rosa, Stephen C. ;

Moodie, Zoe ;

Dubey, Sheri ;

Kierstead, Lisa ;

Janes, Holly ;

Defawe, Olivier D. ;

Carter, Donald K. ;

Hural, John ;

Akondy, Rama ;

Buchbinder, Susan P. ;

Robertson, Michael N. ;

Mehrotra, Devan V. ;

Self, Steven G. ;

Corey, Lawrence ;

Shiver, John W. ;

Casimiro, Danilo R. .

LANCET, 2008, 372 (9653) :1894-1905

[10] Continued Follow-Up of Phambili Phase 2b Randomized HIV-1 Vaccine Trial Participants Supports Increased HIV-1 Acquisition among Vaccinated Men [J].

Moodie, Zoe ;

Metch, Barbara ;

Bekker, Linda-Gail ;

Churchyard, Gavin ;

Nchabeleng, Maphoshane ;

Mlisana, Koleka ;

Laher, Fatima ;

Roux, Surita ;

Mngadi, Kathryn ;

Innes, Craig ;

Mathebula, Matsontso ;

Allen, Mary ;

Bentley, Carter ;

Gilbert, Peter B. ;

Robertson, Michael ;

Kublin, James ;

Corey, Lawrence ;

Gray, Glenda E. .

PLOS ONE, 2015, 10 (09)

← 1 2 →