Phase II Study on Breast Conservative Surgery Plus Chemo-and Radiotherapy in Treating Chinese Patients with Early Staged Breast Cancer

Purpose: To evaluate the efficacy of conservative surgery plus chemo-, radio-therapy in treating patients with early stage breast cancer. Patients and Methods: Eligible patients were treated by postoperative chemotherapy as well as whole-breast irradiation with tumor bed boost. Postoperative radiotherapy consisted of 6 MV whole breast linear accelerator irradiation with two tangential half fields to a total dose of 45 similar to 50 Gy, followed by 10 similar to 15MeV beta boost irradiation to tumor bed for 10 similar to 20Gy, total dose 56 similar to 66Gy. Results: Fifty-two patients were enrolled. Overall 1-, 2- and 3 year survival rates were 98.1%, 92.3%, and 90.4%, respectively, with a local recurrence rate of 5.77%. Cosmetic results were evaluated as good by doctors in 90.4% of patients. Conclusions: Breast conservative surgery combined with chemo-radio-therapy could be a treatment option for Chinese patients with early stage breast cancer.