Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

被引：78

作者：

Rath, Poonam ^{[1
,3
]}

Huang, Chengdong ^{[4
]}

Wang, Tao ^{[5
]}

Wang, Tianzhi ^{[6
]}

Li, Huilin ^{[4
,5
]}

Prados-Rosales, Rafael ^{[7
]}

Elemento, Olivier ^{[2
]}

Casadevall, Arturo ^{[7
]}

Nathan, Carl F. ^{[1
,3
]}

机构：

[1] Weill Cornell Med Coll, Dept Immunol & Microbiol, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA

[3] Cornell Univ, Weill Grad Sch Med Sci, Program Immunol & Microbial Pathogenesis, New York, NY 10065 USA

[4] SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA

[5] Brookhaven Natl Lab, Dept Biosci, Upton, NY 11973 USA

[6] Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA

[7] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 49期

基金：

美国国家卫生研究院;

关键词：

TLR2; macrophages; OUTER-MEMBRANE VESICLES; PROTEIN EXPORT; IN-VITRO; MACROPHAGES; DEFENSE; VACCINATION; PROTECTION; DYNAMICS; SURVIVAL; RELEASE;

D O I：

10.1073/pnas.1320118110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."

引用

页码：E4790 / E4797

页数：8

共 50 条

[21] Host innate immune response to Mycobacterium tuberculosis
Bhatt, Kamlesh
Salgame, Padmini
JOURNAL OF CLINICAL IMMUNOLOGY, 2007, 27 (04) : 347 - 362
[22] Intricate Genetic Programs Controlling Dormancy in Mycobacterium tuberculosis
Peterson, Eliza J. R.
Abidi, Abrar A.
Arrieta-Ortiz, Mario L.
Aguilar, Boris
Yurkovich, James T.
Kaur, Amardeep
Pan, Min
Srinivas, Vivek
Shmulevich, Ilya
Baliga, Nitin S.
CELL REPORTS, 2020, 31 (04):
[23] Mycobacterium tuberculosis Is Able To Accumulate and Utilize Cholesterol
Brzostek, Anna
Pawelczyk, Jakub
Rumijowska-Galewicz, Anna
Dziadek, Bozena
Dziadek, Jaroslaw
JOURNAL OF BACTERIOLOGY, 2009, 191 (21) : 6584 - 6591
[24] Host Innate Immune Response to Mycobacterium tuberculosis
Kamlesh Bhatt
Padmini Salgame
Journal of Clinical Immunology, 2007, 27 : 347 - 362
[25] Direct EPR Detection of Nitric Oxide in Mice Infected with the Pathogenic Mycobacterium Mycobacterium tuberculosis
Vanin, Anatoly F.
Selitskaya, Raisa P.
Serezhenkov, Vladimir A.
Mozhokina, Galina N.
APPLIED MAGNETIC RESONANCE, 2010, 38 (01) : 95 - 104
[26] A selective PPM1A inhibitor activates autophagy to restrict the survival of Mycobacterium tuberculosis
Berton, Stefania
Chen, Lu
Liang, Yi Chu
Xu, Zhongliang
Afriyie-Asante, Afrakoma
Rajabalee, Nusrah
Yang, Weibo
Sun, Jim
CELL CHEMICAL BIOLOGY, 2022, 29 (07) : 1126 - +
[27] Mycobacterium tuberculosis Requires Phosphate-Responsive Gene Regulation To Resist Host Immunity
Tischler, Anna D.
Leistikow, Rachel L.
Kirksey, Meghan A.
Voskuil, Martin I.
McKinney, John D.
INFECTION AND IMMUNITY, 2013, 81 (01) : 317 - 328
[28] Is RORγ a therapeutic target for treating Mycobacterium tuberculosis infections?
Baures, Paul W.
TUBERCULOSIS, 2012, 92 (01) : 95 - 99
[29] The emergence of latent infection in the early evolution of Mycobacterium tuberculosis
Chisholm, Rebecca H.
Tanaka, Mark M.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2016, 283 (1831)
[30] BIFURCATION ANALYSIS FOR AN IN-HOST MYCOBACTERIUM TUBERCULOSIS MODEL
Yao, Miaoran
Zhang, Yongxin
Wang, Wendi
DISCRETE AND CONTINUOUS DYNAMICAL SYSTEMS-SERIES B, 2021, 26 (04): : 2299 - 2322

← 1 2 3 4 5 →