Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

被引：78

作者：

Rath, Poonam ^{[1
,3
]}

Huang, Chengdong ^{[4
]}

Wang, Tao ^{[5
]}

Wang, Tianzhi ^{[6
]}

Li, Huilin ^{[4
,5
]}

Prados-Rosales, Rafael ^{[7
]}

Elemento, Olivier ^{[2
]}

Casadevall, Arturo ^{[7
]}

Nathan, Carl F. ^{[1
,3
]}

机构：

[1] Weill Cornell Med Coll, Dept Immunol & Microbiol, New York, NY 10065 USA

[2] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA

[3] Cornell Univ, Weill Grad Sch Med Sci, Program Immunol & Microbial Pathogenesis, New York, NY 10065 USA

[4] SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA

[5] Brookhaven Natl Lab, Dept Biosci, Upton, NY 11973 USA

[6] Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA

[7] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 49期

基金：

美国国家卫生研究院;

关键词：

TLR2; macrophages; OUTER-MEMBRANE VESICLES; PROTEIN EXPORT; IN-VITRO; MACROPHAGES; DEFENSE; VACCINATION; PROTECTION; DYNAMICS; SURVIVAL; RELEASE;

D O I：

10.1073/pnas.1320118110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."

引用

页码：E4790 / E4797

页数：8

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