Genetic regulation of vesiculogenesis and immunomodulation in Mycobacterium tuberculosis

被引：78
|
作者：
Rath, Poonam [1 ,3 ]
Huang, Chengdong [4 ]
Wang, Tao [5 ]
Wang, Tianzhi [6 ]
Li, Huilin [4 ,5 ]
Prados-Rosales, Rafael [7 ]
Elemento, Olivier [2 ]
Casadevall, Arturo [7 ]
Nathan, Carl F. [1 ,3 ]
机构：
[1] Weill Cornell Med Coll, Dept Immunol & Microbiol, New York, NY 10065 USA
[2] Weill Cornell Med Coll, Dept Physiol & Biophys, New York, NY 10065 USA
[3] Cornell Univ, Weill Grad Sch Med Sci, Program Immunol & Microbial Pathogenesis, New York, NY 10065 USA
[4] SUNY Stony Brook, Dept Biochem & Cell Biol, Stony Brook, NY 11794 USA
[5] Brookhaven Natl Lab, Dept Biosci, Upton, NY 11973 USA
[6] Univ Texas Med Branch, Sealy Ctr Struct Biol & Mol Biophys, Galveston, TX 77555 USA
[7] Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 49期
基金：
美国国家卫生研究院;
关键词：
TLR2; macrophages; OUTER-MEMBRANE VESICLES; PROTEIN EXPORT; IN-VITRO; MACROPHAGES; DEFENSE; VACCINATION; PROTECTION; DYNAMICS; SURVIVAL; RELEASE;
D O I：
10.1073/pnas.1320118110
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Mycobacterium tuberculosis (Mtb) restrains immune responses well enough to escape eradication but elicits enough immunopathology to ensure its transmission. Here we provide evidence that this host-pathogen relationship is regulated in part by a cytosolic, membrane-associated protein with a unique structural fold, encoded by the Mtb gene rv0431. The protein acts by regulating the quantity of Mtb-derived membrane vesicles bearing Toll-like receptor 2 ligands, including the lipoproteins LpqH and SodC. We propose that rv0431 be named "vesiculogenesis and immune response regulator."
引用
收藏
页码：E4790 / E4797
页数：8
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