A debate on current eating disorder diagnoses in light of neurobiological findings: is it time for a spectrum model?

被引:92
作者
Brooks, Samantha Jane [1 ]
Rask-Andersen, Mathias [1 ]
Benedict, Christian [1 ]
Schioth, Helgi Birgir [1 ]
机构
[1] Uppsala Univ, Dept Neurosci, Uppsala, Sweden
基金
瑞典研究理事会;
关键词
DSM; Anorexia; Bulimia; Binge-eating; Genetic; fMRI; NEUROTROPHIC FACTOR GENE; BODY-MASS-INDEX; ANOREXIA-NERVOSA; PREFRONTAL CORTEX; BULIMIA-NERVOSA; RISK-FACTORS; WEIGHT-LOSS; COMT GENE; ASSOCIATION; BDNF;
D O I
10.1186/1471-244X-12-76
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Sixty percent of eating disorders do not meet criteria for anorexia- or bulimia nervosa, as defined by the Diagnostic and Statistical Manual version 4 (DSM-IV). Instead they are diagnosed as 'eating disorders not otherwise specified' (EDNOS). Discrepancies between criteria and clinical reality currently hampering eating disorder diagnoses in the DSM-IV will be addressed by the forthcoming DSM-V. However, future diagnoses for eating disorders will rely on current advances in the fields of neuroimaging and genetics for classification of symptoms that will ultimately improve treatment. Discussion: Here we debate the classification issues, and discuss how brain imaging and genetic discoveries might be interwoven into a model of eating disorders to provide better classification and treatment. The debate concerns: a) current issues in the classification of eating disorders in the DSM-IV, b) changes proposed for DSM-V, c) neuroimaging eating disorder research and d) genetic eating disorder research. Summary: We outline a novel evidence-based 'impulse control' spectrum model of eating disorders. A model of eating disorders is proposed that will aid future diagnosis of symptoms, coinciding with contemporary suggestions by clinicians and the proposed changes due to be published in the DSM-V.
引用
收藏
页数:11
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