A debate on current eating disorder diagnoses in light of neurobiological findings: is it time for a spectrum model?

被引:92
作者
Brooks, Samantha Jane [1 ]
Rask-Andersen, Mathias [1 ]
Benedict, Christian [1 ]
Schioth, Helgi Birgir [1 ]
机构
[1] Uppsala Univ, Dept Neurosci, Uppsala, Sweden
基金
瑞典研究理事会;
关键词
DSM; Anorexia; Bulimia; Binge-eating; Genetic; fMRI; NEUROTROPHIC FACTOR GENE; BODY-MASS-INDEX; ANOREXIA-NERVOSA; PREFRONTAL CORTEX; BULIMIA-NERVOSA; RISK-FACTORS; WEIGHT-LOSS; COMT GENE; ASSOCIATION; BDNF;
D O I
10.1186/1471-244X-12-76
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Background: Sixty percent of eating disorders do not meet criteria for anorexia- or bulimia nervosa, as defined by the Diagnostic and Statistical Manual version 4 (DSM-IV). Instead they are diagnosed as 'eating disorders not otherwise specified' (EDNOS). Discrepancies between criteria and clinical reality currently hampering eating disorder diagnoses in the DSM-IV will be addressed by the forthcoming DSM-V. However, future diagnoses for eating disorders will rely on current advances in the fields of neuroimaging and genetics for classification of symptoms that will ultimately improve treatment. Discussion: Here we debate the classification issues, and discuss how brain imaging and genetic discoveries might be interwoven into a model of eating disorders to provide better classification and treatment. The debate concerns: a) current issues in the classification of eating disorders in the DSM-IV, b) changes proposed for DSM-V, c) neuroimaging eating disorder research and d) genetic eating disorder research. Summary: We outline a novel evidence-based 'impulse control' spectrum model of eating disorders. A model of eating disorders is proposed that will aid future diagnosis of symptoms, coinciding with contemporary suggestions by clinicians and the proposed changes due to be published in the DSM-V.
引用
收藏
页数:11
相关论文
共 94 条
[11]   PERCEPTUAL AND CONCEPTUAL DISTURBANCES IN ANOREXIA-NERVOSA [J].
BRUCH, H .
PSYCHOSOMATIC MEDICINE, 1962, 24 (02) :187-+
[12]   Prevalence, heritability, and prospective risk factors for anorexia nervosa [J].
Bulik, CM ;
Sullivan, PF ;
Tozzi, F ;
Furberg, H ;
Lichtenstein, P ;
Pedersen, NL .
ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (03) :305-312
[13]   Relation of dietary restraint scores to activation of reward-related brain regions in response to food intake, anticipated intake, and food pictures [J].
Burger, Kyle S. ;
Stice, Eric .
NEUROIMAGE, 2011, 55 (01) :233-239
[14]   Eating disorders, gene-environment interactions and epigenetics [J].
Campbell, Iain C. ;
Mill, Jonathan ;
Uher, Rudolf ;
Schmidt, Ulrike .
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS, 2011, 35 (03) :784-793
[15]   Neuroimaging and obesity: current knowledge and future directions [J].
Carnell, S. ;
Gibson, C. ;
Benson, L. ;
Ochner, C. N. ;
Geliebter, A. .
OBESITY REVIEWS, 2012, 13 (01) :43-56
[16]   Association between 5-HT2A gene promoter polymorphism and anorexia nervosa [J].
Collier, DA ;
Arranz, MJ ;
Li, T ;
Mupita, D ;
Brown, N ;
Treasure, J .
LANCET, 1997, 350 (9075) :412-412
[17]   What is recovery in adolescent anorexia nervosa? [J].
Couturier, Jennifer ;
Lock, James .
INTERNATIONAL JOURNAL OF EATING DISORDERS, 2006, 39 (07) :550-555
[18]   How do you feel - now? The anterior insula and human awareness [J].
Craig, A. D. .
NATURE REVIEWS NEUROSCIENCE, 2009, 10 (01) :59-70
[19]   Family trios analysis of common polymorphisms in the obestatin/ghrelin, BDNF and AGRP genes in patients with Anorexia nervosa: Association with subtype, body-mass index, severity and age of onset [J].
Dardennes, Roland M. ;
Zizzari, Philippe ;
Tolle, Virginie ;
Foulon, Christine ;
Kipman, Amelie ;
Romo, Lucia ;
Iancu-Gontard, Dana ;
Boni, Claudette ;
Sinet, Pierre-Marie ;
Bluet, Marie Therese ;
Estour, Bruno ;
Mouren, Marie-Christine ;
Guelfi, Julien-Daniel ;
Rouillon, Frederic ;
Gorwood, Philip ;
Epelbaum, Jacques .
PSYCHONEUROENDOCRINOLOGY, 2007, 32 (02) :106-113
[20]   Polymorphisms in the brain-derived neurotrophic factor gene are not associated with either anorexia nervosa or schizophrenia in Dutch patients [J].
de Krom, M ;
Bakker, SC ;
Hendriks, J ;
van Elburg, A ;
Hoogendoorn, M ;
Verduijn, W ;
Sinke, R ;
Kahn, R ;
Adan, RAH .
PSYCHIATRIC GENETICS, 2005, 15 (02) :81-81