CTLA-4 blockade synergizes with cryoablation to mediate tumor rejection

被引：26
|
作者：
Waitz, Rebecca [1 ]
Fasso, Marcella [2 ]
Allison, James P. [1 ]
机构：
[1] Mem Sloan Kettering Canc Ctr, Howard Hughes Med Inst, Dept Immunol, New York, NY 10021 USA
[2] Univ Calif San Francisco, San Francisco, CA 94143 USA
来源：
ONCOIMMUNOLOGY | 2012年 / 1卷 / 04期
关键词：
cryoablation; CTLA-4; Ipilumimab; SPAS-1; prostate cancer; COMBINATION IMMUNOTHERAPY; CANCER; IMMUNITY; MELANOMA;
D O I：
10.4161/onci.19442
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We report that cryoablation of primary tumors synergizes with anti-CTLA-4 treatment to mediate rejection of secondary tumors in the TRAMP mouse model of prostate cancer. T cells, in particular CD8(+) T cells specific for the TRAMP antigen SPAS-1, were enriched in both secondary tumors and spleens of combination-treated mice.
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页数：3
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