Myelin basic protein in cerebrospinal fluid: a predictive marker of delayed encephalopathy from carbon monoxide poisoning

被引：29

作者：

Ide, Toshimitsu ^{[1
]}

Kamijo, Yoshito ^{[2
]}

机构：

[1] Kitasato Univ, Sch Med, Dept Neurol, Sagamihara Kanagawa 2288555, Japan

[2] Kitasato Univ, Sch Med, Dept Emergency & Crit Care Med, Sagamihara Kanagawa 2288555, Japan

来源：

AMERICAN JOURNAL OF EMERGENCY MEDICINE | 2008年 / 26卷 / 08期

关键词：

D O I：

10.1016/j.ajem.2007.11.021

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

This study was designed to investigate whether myelin basic protein (MBP) in cerebrospinal fluid (CSF) can be a predictive marker of delayed encephalopathy from carbon monoxide (CO) poisoning. Five patients with CO poisoning were included in the study. The CSF was serially sampled to determine the MBP concentration. All patients were classified into group DE or group non-DE according to whether delayed encephalopathy developed or not. In all 3 patients in group DE, the MBP levels in the CSF were markedly elevated preceding the clinical manifestations of delayed encephalopathy. In both group non-DE patients, the MBP concentrations in the CSF were never elevated. Elevated MBP concentrations in the CSF may represent a predictive marker of delayed encephalopathy from CO poisoning, leading to a more appropriate triage of patients with CO poisoning. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：908 / 912

页数：5

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