Alpha-fetoprotein receptor as an early indicator of HBx-driven hepatocarcinogenesis and its applications in tracing cancer cell metastasis

被引：35
作者：
Li, Mengsen [1 ,2 ]
Zhu, Mingyue [1 ,2 ]
Li, Wei [1 ,2 ]
Lu, Yan [1 ,2 ]
Xie, Xieju [3 ]
Wu, Yuqiang [4 ]
Zheng, Shaojiang [2 ,5 ]
机构：
[1] Hainan Med Coll, Key Lab Mol Biol, Haikou 571199, Peoples R China
[2] Hainan Med Coll, Hainan Prov Key Lab Carcinogenesis & Intervent, Haikou 571199, Peoples R China
[3] Hainan Med Coll, Dept Pathophysiol, Haikou 571199, Peoples R China
[4] Hainan Prov People Hosp, Dept Hepatobiliary Surg, Haikou 570232, Peoples R China
[5] Hainan Med Coll, Dept Pathol, Haikou 571199, Peoples R China
来源：
CANCER LETTERS | 2013年 / 330卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Alpha-fetoprotein receptor; Hepatitis B virus x protein; Hepatocellular carcinoma; Cancer cell metastasis; HEPATOCELLULAR-CARCINOMA; PROLIFERATION; PROTEIN; GROWTH; CARCINOGENESIS; ACTIVATION; EXPRESSION; MECHANISM; PATHWAY; PI3K;
D O I：
10.1016/j.canlet.2012.11.042
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
AFP and its receptor (AFPR) are early indicators of HBx-driven hepatocarcinogenesis. Clinical specimens, normal human liver cells L-02 and HCC cell lines were selected for analyzing the effects of HBx on expression of AFP, AFPR, Src, CXCR4, and Ras. Results showed that AFPR localized in the membranes of HCC samples. HBx upregulated the expression of AFPR and AFP prior to expression of Src, CXCR4, and Ras in L-02 cells and in liver specimens; Target-labeled AFPR was able to reveal the location and metastatic status of HCC in vivo. In this way, actuated expression of AFPR served as an indicator suitable for use in the early diagnosis of HBx-driven malignant transformation of hepatocytes. Labeled AFPR may be applied to trace primary and metastatic HCC. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：170 / 180
页数：11
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