Detection of floccular hypometabolism in downbeat nystagmus by fMRI

被引：65

作者：

Kalla, R ^{[1
]}

Deutschlander, A ^{[1
]}

Hufner, K ^{[1
]}

Stephan, T ^{[1
]}

Jahn, K ^{[1
]}

Glasauer, S ^{[1
]}

Brandt, T ^{[1
]}

Strupp, M ^{[1
]}

机构：

[1] Univ Munich, Dept Neurol, D-8000 Munich, Germany

来源：

NEUROLOGY | 2006年 / 66卷 / 02期

关键词：

D O I：

10.1212/01.wnl.0000194242.28018.d9

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors evaluated floccular activity with fMRI during the performance of vertical smooth pursuit eye movements in four patients with downbeat nystagmus (DBN) due to cerebellar degeneration and in 16 healthy controls. Region of interest analysis revealed a significantly diminished activation of both floccular lobes during downward but not upward pursuit in DBN. These imaging data support the view that a functional deficiency of the flocculi in downward pursuit causes DBN.

引用

页码：281 / 283

页数：3

共 10 条

[1] [Anonymous], 1999, The Neurology of Eye Movements
[2] Smooth pursuit in patients with downbeat nystagmus
Glasauer, S
Hoshi, M
Büttner, U
[J]. CLINICAL AND BASIC OCULOMOTOR RESEARCH: IN HONOR OF DAVID S. ZEE, 2005, 1039 : 532 - 535
[3] Vertical vestibular responses to head impulses are symmetric in downbeat nystagmus
Glasauer, S
von Lindeiner, H
Siebold, C
Büttner, U
[J]. NEUROLOGY, 2004, 63 (04) : 621 - 625
[4] The origin of downbeat nystagmus - An asymmetry in the distribution of on-directions of vertical gaze-velocity Purkinje cells
Marti, S
Straumann, D
Glasauer, S
[J]. CLINICAL AND BASIC OCULOMOTOR RESEARCH: IN HONOR OF DAVID S. ZEE, 2005, 1039 : 548 - 553
[5] Vertical nystagmus: clinical facts and hypotheses
Pierrot-Deseilligny, C
Milea, D
[J]. BRAIN, 2005, 128 : 1237 - 1246
[6] Functional MRI of galvanic vestibular stimulation with alternating currents at different frequencies
Stephan, T
Deutschländer, A
Nolte, A
Schneider, E
Wiesmann, M
Brandt, T
Dieterich, M
[J]. NEUROIMAGE, 2005, 26 (03) : 721 - 732
[7] STEPHAN T, 2005, 11 ANN M HUM BRAIN
[8] VISUAL RESPONSES OF PURKINJE-CELLS IN THE CEREBELLAR FLOCCULUS DURING SMOOTH-PURSUIT EYE-MOVEMENTS IN MONKEYS .1. SIMPLE SPIKES
STONE, LS
LISBERGER, SG
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1990, 63 (05) : 1241 - 1261
[9] Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain
Tzourio-Mazoyer, N
Landeau, B
Papathanassiou, D
Crivello, F
Etard, O
Delcroix, N
Mazoyer, B
Joliot, M
[J]. NEUROIMAGE, 2002, 15 (01) : 273 - 289
[10] EFFECTS OF ABLATION OF FLOCCULUS AND PARAFLOCCULUS ON EYE-MOVEMENTS IN PRIMATE
ZEE, DS
YAMAZAKI, A
BUTLER, PH
GUCER, G
[J]. JOURNAL OF NEUROPHYSIOLOGY, 1981, 46 (04) : 878 - 899

← 1 →