Mesenchymal Stromal Cells and Natural Killer Cells: A Complex Story of Love and Hate

被引：9

作者：

Najar, Mehdi ^{[1
,2
,3
]}

Fayyad-Kazan, Mohammad ^{[4
]}

Merimi, Makram ^{[4
]}

Burny, Arsene ^{[4
]}

Bron, Dominique ^{[4
]}

Fayyad-Kazan, Hussein ^{[5
]}

Meuleman, Nathalie ^{[6
]}

Lagneaux, Laurence ^{[7
]}

机构：

[1] Univ Montreal, Osteoarthritis Res Unit, Univ Montreal Hosp Res Ctr CRCHUM, Montreal, PQ, Canada

[2] Univ Montreal, Dept Med, Montreal, PQ, Canada

[3] Univ Mohammed Premier, Lab Physiol Ethnopharmacol & Genet, Fac Sci, Oujda, Morocco

[4] Univ Libre Bruxelles, Inst Jules Bordet, Lab Expt Hematol, 121 Blvd Waterloo, B-1000 Brussels, Belgium

[5] Lebanese Univ, Lab Canc Biol & Mol Immunol, Fac Sci 1, Hadath, Lebanon

[6] Univ Libre Bruxelles, Inst Jules Bordet, Hematol Dept, 121 Blvd Waterloo, B-1000 Brussels, Belgium

[7] Univ Libre Bruxelles, Inst Jules Bordet, Lab Clin Cell Therapy, Campus Erasme, Brussels, Belgium

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2019年 / 14卷 / 01期

关键词：

Mesenchymal stromal cells; natural killer cells; immunomodulation; cellular cytotoxicity; natural killer receptors; cytokines; STEM-CELLS; NK CELLS; CYTOKINE PRODUCTION; INTERFERON-GAMMA; T-CELLS; IN-VIVO; INHIBIT; ACTIVATION; INDUCE; ADULT;

D O I：

10.2174/1574888X13666180912125736

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Mesenchymal Stromal Cells (MSCs), characterized by both multidifferentiation potential and potent immunomodulatory capacity, represent a promising, safe and powerful cell based-therapy for repairing tissue damage and/or treating diseases associated with aberrant immune responses. Natural Killer (NK) cells are granular lymphocytes of the innate immune system that function alone or in combination with other immune cells to combat both tumors and virally infected cells. After their infusion, MSCs are guided by host inflammatory elements and can interact with different immune cells, particularly those of the innate immune system. Although some breakthroughs have been achieved in understanding these interactions, much remains to be determined. In this review, we discuss the complex interactions between NK cells and MSCs, particularly the importance of improving the therapeutic value of MSCs.

引用

页码：14 / 21

页数：8

共 67 条

[1] Characterization of the interaction between human decidua parietalis mesenchymal stem/stromal cells and natural killer cells [J].