Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

被引：121

作者：

Broderick, Peter ^{[1
]}

Chubb, Daniel ^{[1
]}

Johnson, David C. ^{[2
]}

Weinhold, Niels ^{[3
]}

Foersti, Asta ^{[4
]}

Lloyd, Amy ^{[1
]}

Olver, Bianca ^{[1
]}

Ma, Yussanne P. ^{[1
]}

Dobbins, Sara E. ^{[1
]}

Walker, Brian A. ^{[2
]}

Davies, Faith E. ^{[2
]}

Gregory, Walter A. ^{[5
]}

Child, J. Anthony ^{[5
]}

Ross, Fiona M. ^{[6
]}

Jackson, Graham H. ^{[7
]}

Neben, Kai ^{[3
]}

Jauch, Anna ^{[8
]}

Hoffmann, Per ^{[9
]}

Muehleisen, Thomas W. ^{[9
]}

Noethen, Markus M. ^{[9
,10
]}

Moebus, Susanne ^{[11
]}

Tomlinson, Ian P. ^{[12
]}

Goldschmidt, Hartmut ^{[3
,13
]}

Hemminki, Kari ^{[14
]}

Morgan, Gareth J. ^{[2
]}

Houlston, Richard S. ^{[1
,2
]}

机构：

[1] Inst Canc Res, Div Genet & Epidemiol, Surrey, England

[2] Inst Canc Res, Div Mol Pathol, Haematooncol Res Unit, Surrey, England

[3] Univ Heidelberg, Dept Internal Med 5, Heidelberg, Germany

[4] German Canc Res Ctr, D-6900 Heidelberg, Germany

[5] Univ Leeds, Clin Trials Res Unit, Leeds, W Yorkshire, England

[6] Wessex Reg Cytogenet Lab, Cytogenet Grp, Salisbury, Wilts, England

[7] Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[8] Univ Heidelberg, Inst Human Genet, Heidelberg, Germany

[9] Univ Bonn, Inst Human Genet, Bonn, Germany

[10] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[11] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany

[12] Wellcome Trust Ctr Human Genet, Oxford, England

[13] Natl Ctr Tumour Dis, Heidelberg, Germany

[14] Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden

来源：

NATURE GENETICS | 2012年 / 44卷 / 01期

关键词：

GENOME-WIDE ASSOCIATION; UNDETERMINED SIGNIFICANCE; MONOCLONAL GAMMOPATHY; SUSCEPTIBILITY LOCI; STRATIFICATION; CLASSIFICATION; ABNORMALITIES; PATHOGENESIS; METAANALYSIS; PROGNOSIS;

D O I：

10.1038/ng.993

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

引用

页码：58 / U83

页数：6

共 43 条

[1] Familial risks and temporal incidence trends of multiple myeloma
Altieri, Andrea
Chen, Bowang
Bermejo, Justo Lorenzo
Castro, Felipe
Hemminki, Kari
[J]. EUROPEAN JOURNAL OF CANCER, 2006, 42 (11) : 1661 - 1670
[2] β-dystrobrevin, a member of the dystrophin-related protein family
Blake, DJ
Nawrotzki, R
Loh, NY
Górecki, DC
Davies, KE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (01) : 241 - 246
[3] Deletion of chromosome 13 detected by conventional cytogenetics is a critical prognostic factor in myeloma
Chiecchio, L.
Protheroe, R. K. M.
Ibrahim, A. H.
Cheung, K. L.
Rudduck, C.
Dagrada, G. P.
Cabanas, E. D.
Parker, T.
Nightingale, M.
Wechalekar, A.
Orchard, K. H.
Harrison, C. J.
Cross, N. C. P.
Morgan, G. J.
Ross, F. M.
[J]. LEUKEMIA, 2006, 20 (09) : 1610 - 1617
[4] Population structure, differential bias and genomic control in a large-scale, case-control association study
Clayton, DG
Walker, NM
Smyth, DJ
Pask, R
Cooper, JD
Maier, LM
Smink, LJ
Lam, AC
Ovington, NR
Stevens, HE
Nutland, S
Howson, JMM
Faham, M
Moorhead, M
Jones, HB
Falkowski, M
Hardenbol, P
Willis, TD
Todd, JA
[J]. NATURE GENETICS, 2005, 37 (11) : 1243 - 1246
[5] Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk
Crowther-Swanepoel, Dalemari
Broderick, Peter
Di Bernardo, Maria Chiara
Dobbins, Sara E.
Torres, Maria
Mansouri, Mahmoud
Ruiz-Ponte, Clara
Enjuanes, Anna
Rosenquist, Richard
Carracedo, Angel
Jurlander, Jesper
Campo, Elias
Juliusson, Gunnar
Montserrat, Emilio
Smedby, Karin E.
Dyer, Martin J. S.
Matutes, Estella
Dearden, Claire
Sunter, Nicola J.
Hall, Andrew G.
Mainou-Fowler, Tryfonia
Jackson, Graham H.
Summerfield, Geoffrey
Harris, Robert J.
Pettitt, Andrew R.
Allsup, David J.
Bailey, James R.
Pratt, Guy
Pepper, Chris
Fegan, Chris
Parker, Anton
Oscier, David
Allan, James M.
Catovsky, Daniel
Houlston, Richard S.
[J]. NATURE GENETICS, 2010, 42 (02) : 132 - U59
[6] A WILCOXON-TYPE TEST FOR TREND
CUZICK, J
[J]. STATISTICS IN MEDICINE, 1985, 4 (01) : 87 - 90
[7] Chromosome abnormalities clustering and its implications for pathogenesis and prognosis in myeloma
Debes-Marun, CS
Dewald, GW
Bryant, S
Picken, E
Santana-Dávila, R
González-Paz, N
Winkler, JM
Kyle, RA
Gertz, MA
Witzig, TE
Dispenzieri, A
Lacy, MQ
Rajkumar, SV
Lust, JA
Greipp, PR
Fonseca, R
[J]. LEUKEMIA, 2003, 17 (02) : 427 - 436
[8] DEWALD GW, 1985, BLOOD, V66, P380
[9] Dib Amel, 2008, J Natl Cancer Inst Monogr, P25, DOI 10.1093/jncimonographs/lgn011
[10] A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3)
Enciso-Mora, Victor
Broderick, Peter
Ma, Yussanne
Jarrett, Ruth F.
Hjalgrim, Henrik
Hemminki, Kari
van den Berg, Anke
Olver, Bianca
Lloyd, Amy
Dobbins, Sara E.
Lightfoot, Tracy
van Leeuwen, Flora E.
Foersti, Asta
Diepstra, Arjan
Broeks, Annegien
Vijayakrishnan, Jayaram
Shield, Lesley
Lake, Annette
Montgomery, Dorothy
Roman, Eve
Engert, Andreas
von Strandmann, Elke Pogge
Reiners, Katrin S.
Nolte, Ilja M.
Smedby, Karin E.
Adami, Hans-Olov
Russell, Nicola S.
Glimelius, Bengt
Hamilton-Dutoit, Stephen
de Bruin, Marieke
Ryder, Lars P.
Molin, Daniel
Sorensen, Karina Meden
Chang, Ellen T.
Taylor, Malcolm
Cooke, Rosie
Hofstra, Robert
Westers, Helga
van Wezel, Tom
van Eijk, Ronald
Ashworth, Alan
Rostgaard, Klaus
Melbye, Mads
Swerdlow, Anthony J.
Houlston, Richard S.
[J]. NATURE GENETICS, 2010, 42 (12) : 1126 - +

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