Common variation at 3p22.1 and 7p15.3 influences multiple myeloma risk

被引：123

作者：

Broderick, Peter ^{[1
]}

Chubb, Daniel ^{[1
]}

Johnson, David C. ^{[2
]}

Weinhold, Niels ^{[3
]}

Foersti, Asta ^{[4
]}

Lloyd, Amy ^{[1
]}

Olver, Bianca ^{[1
]}

Ma, Yussanne P. ^{[1
]}

Dobbins, Sara E. ^{[1
]}

Walker, Brian A. ^{[2
]}

Davies, Faith E. ^{[2
]}

Gregory, Walter A. ^{[5
]}

Child, J. Anthony ^{[5
]}

Ross, Fiona M. ^{[6
]}

Jackson, Graham H. ^{[7
]}

Neben, Kai ^{[3
]}

Jauch, Anna ^{[8
]}

Hoffmann, Per ^{[9
]}

Muehleisen, Thomas W. ^{[9
]}

Noethen, Markus M. ^{[9
,10
]}

Moebus, Susanne ^{[11
]}

Tomlinson, Ian P. ^{[12
]}

Goldschmidt, Hartmut ^{[3
,13
]}

Hemminki, Kari ^{[14
]}

Morgan, Gareth J. ^{[2
]}

Houlston, Richard S. ^{[1
,2
]}

机构：

[1] Inst Canc Res, Div Genet & Epidemiol, Surrey, England

[2] Inst Canc Res, Div Mol Pathol, Haematooncol Res Unit, Surrey, England

[3] Univ Heidelberg, Dept Internal Med 5, Heidelberg, Germany

[4] German Canc Res Ctr, D-6900 Heidelberg, Germany

[5] Univ Leeds, Clin Trials Res Unit, Leeds, W Yorkshire, England

[6] Wessex Reg Cytogenet Lab, Cytogenet Grp, Salisbury, Wilts, England

[7] Royal Victoria Infirm, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[8] Univ Heidelberg, Inst Human Genet, Heidelberg, Germany

[9] Univ Bonn, Inst Human Genet, Bonn, Germany

[10] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[11] Univ Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol, Essen, Germany

[12] Wellcome Trust Ctr Human Genet, Oxford, England

[13] Natl Ctr Tumour Dis, Heidelberg, Germany

[14] Lund Univ, Ctr Primary Hlth Care Res, Malmo, Sweden

来源：

NATURE GENETICS | 2012年 / 44卷 / 01期

关键词：

GENOME-WIDE ASSOCIATION; UNDETERMINED SIGNIFICANCE; MONOCLONAL GAMMOPATHY; SUSCEPTIBILITY LOCI; STRATIFICATION; CLASSIFICATION; ABNORMALITIES; PATHOGENESIS; METAANALYSIS; PROGNOSIS;

D O I：

10.1038/ng.993

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To identify risk variants for multiple myeloma, we conducted a genome-wide association study of 1,675 individuals with multiple myeloma and 5,903 control subjects. We identified risk loci for multiple myeloma at 3p22.1 (rs1052501 in ULK4; odds ratio (OR) = 1.32; P = 7.47 x 10(-9)) and 7p15.3 (rs4487645, OR = 1.38; P = 3.33 x 10(-15)). In addition, we observed a promising association at 2p23.3 (rs6746082, OR = 1.29; P = 1.22 x 10(-7)). Our study identifies new genomic regions associated with multiple myeloma risk that may lead to new etiological insights.

引用

页码：58 / U83

页数：6

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