Structural characterization and stability study of green synthesized starch stabilized silver nanoparticles loaded with isoorientin

被引：26
作者：
Wang, Xiao [1 ]
Yuan, Li [1 ]
Deng, Hong [1 ]
Zhang, Zhong [1 ]
机构：
[1] Shaanxi Normal Univ, Engn Res Ctr High Value Utilizat Western China Fr, Coll Food Engn & Nutr Sci, Xian 710119, Peoples R China
来源：
FOOD CHEMISTRY | 2021年 / 338卷
基金：
中国国家自然科学基金;
关键词：
Isoorientin; Silver nanoparticles; Structural characterization; Stability; Digestion in vitro; ZINC-OXIDE NANOPARTICLES; IN-VITRO; SIGNALING PATHWAY; ANTIOXIDANT; FABRICATION; INHIBITOR; EMULSIONS; APOPTOSIS; CURCUMIN; DELIVERY;
D O I：
10.1016/j.foodchem.2020.127807
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Isoorientin (Iso) is a natural flavonoid, the effect of metal nanoparticles loaded with it was unknown. In this study, silver nanoparticles (AgNPs) were synthesized by corn starch and sodium citrate with the green synthesis method, and the structural characterization and stability of AgNPs loaded with Iso (AgNPs-Iso) were examined by UV-vis spectroscopy and zetasizer. Results showed that AgNPs (65 +/- 0.87 nm, spheres) successfully loaded with Iso (117 +/- 2.13 nm, loading efficiency: 76.60%). There are no significant changes of the stability of AgNPs and AgNPs-Iso in pH 5-9 and 0-0.30 M of NaCl solution. AgNPs-Iso was more stable than AgNPs in the simulated gastrointestinal digestion in vitro. Furthermore, AgNPs-Iso showed the lower erythrocytes hemolysis ratio and cytotoxicity, and exhibited a notably inhibitive effect on a-glucosidase and pancreatic lipase. Therefore, this study could provide the basic support for the further development of highly stable and lowly cytotoxic AgNPs-Iso on Type II diabetes and obesity.
引用
收藏
页数：10
相关论文
共 39 条
[1]   Synthesis of water soluble glycine capped silver nanoparticles and their surface selective interaction [J].
Agasti, Nityananda ;
Singh, Vinay K. ;
Kaushik, N. K. .
MATERIALS RESEARCH BULLETIN, 2015, 64 :17-21
[2]   Aloe vera extract functionalized zinc oxide nanoparticles as nanoantibiotics against multi-drug resistant clinical bacterial isolates [J].
Ali, Khursheed ;
Dwivedi, Sourabh ;
Azam, Ameer ;
Saquib, Quaiser ;
Al-Said, Mansour S. ;
Alkhedhairy, Abdulaziz A. ;
Musarrat, Javed .
JOURNAL OF COLLOID AND INTERFACE SCIENCE, 2016, 472 :145-156
[3]   Chemistry, structure, functionality and applications of rice starch [J].
Amagliani, Luca ;
O'Regan, Jonathan ;
Kelly, Alan L. ;
O'Mahony, James A. .
JOURNAL OF CEREAL SCIENCE, 2016, 70 :291-300
[4]   Antimicrobial activities of green synthesized gums-stabilized nanoparticles loaded with flavonoids [J].
Anwar, Ayaz ;
Masri, Abdulkader ;
Rao, Komal ;
Rajendran, Kavitha ;
Khan, Naveed Ahmed ;
Shah, Muhammad Raza ;
Siddiqui, Ruqaiyyah .
SCIENTIFIC REPORTS, 2019, 9 (1)
[5]   Characterization of mucin - lipid droplet interactions: Influence on potential fate of fish oil-in-water emulsions under simulated gastrointestinal conditions [J].
Chang, Yaoguang ;
McClements, David Julian .
FOOD HYDROCOLLOIDS, 2016, 56 :425-433
[6]   Biosynthesis of Silver Nanoparticles from Melia azedarach: Enhancement of Antibacterial, Wound Healing, Antidiabetic and Antioxidant Activities [J].
Chinnasamy, Gandhimathi ;
Chandrasekharan, Smitha ;
Bhatnagar, Somika .
INTERNATIONAL JOURNAL OF NANOMEDICINE, 2019, 14 :9823-9836
[7]   Encapsulation of resveratrol in biopolymer particles produced using liquid antisolvent precipitation. Part 1: Preparation and characterization [J].
Davidov-Pardo, Gabriel ;
Joye, Iris J. ;
McClements, David Julian .
FOOD HYDROCOLLOIDS, 2015, 45 :309-316
[8]   Development of Orally Applicable, Combinatorial Drug-Loaded Nanoparticles for the Treatment of Fibrosarcoma [J].
Demirbolat, Gulen Melike ;
Altintas, Levent ;
Yilmaz, Sukran ;
Degim, Ismail Tuncer .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2018, 107 (05) :1398-1407
[9]   Polymeric nanoparticles loaded with the 3,5,3 '-triiodothyroacetic acid (Triac), a thyroid hormone: factorial design, characterization, and release kinetics [J].
dos Santos, Karen C. ;
da Silva, Maria Fatima G. F. ;
Pereira-Filho, Edenir R. ;
Fernandes, Joao B. ;
Polikarpov, Igor ;
Forim, Moacir R. .
NANOTECHNOLOGY SCIENCE AND APPLICATIONS, 2012, 5 :37-48
[10]   Isoorientin Ameliorates APAP-Induced Hepatotoxicity via Activation Nrf2 Antioxidative Pathway: The Involvement of AMPK/Akt/GSK3β [J].
Fan, Xiaoye ;
Lv, Hongming ;
Wang, Lidong ;
Deng, Xuming ;
Ci, Xinxin .
FRONTIERS IN PHARMACOLOGY, 2018, 9
1234