Cannabinoids and neuroinflammation

被引：274
作者：
Walter, L
Stella, N [1 ]
机构：
[1] Univ Washington, Dept Pharmacol, Seattle, WA 98195 USA
[2] Univ Washington, Dept Psychiat & Biobehav Sci, Seattle, WA 98195 USA
来源：
BRITISH JOURNAL OF PHARMACOLOGY | 2004年 / 141卷 / 05期
关键词：
cannabinoid; glia; immune cells; inflammation; multiple sclerosis;
D O I：
10.1038/sj.bjp.0705667
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Growing evidence suggests that a major physiological function of the cannabinoid signaling system is to modulate neuroinflammation. This review discusses the anti-inflammatory properties of cannabinoid compounds at molecular, cellular and whole animal levels, first by examining the evidence for anti-inflammatory effects of cannabinoids obtained using in vivo animal models of clinical neuroinflammatory conditions, specifically rodent models of multiple sclerosis, and second by describing the endogenous cannabinoid (endocannabinoid) system components in immune cells. Our aim is to identify immune functions modulated by cannabinoids that could account for their antiinflammatory effects in these animal models.
引用
收藏
页码：775 / 785
页数：11
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