The value of delta neutrophil index in young infants with febrile urinary tract infection

被引：14

作者：

Lee, Jung Won ^{[1
]}

Kim, Seong Heon ^{[2
]}

Park, Se Jin ^{[3
]}

Lee, Keum Hwa ^{[4
,5
]}

Park, Jae Hyon ^{[6
]}

Kronbichler, Andreas ^{[7
]}

Eisenhut, Michael ^{[8
]}

Kim, Ji Hong ^{[4
]}

Lee, Jong Wook ^{[9
,10
]}

Shin, Jae Il ^{[4
,5
,11
]}

机构：

[1] Ewha Womans Univ, Sch Med, Dept Pediat, Seoul, South Korea

[2] Pusan Natl Univ, Childrens Hosp, Dept Pediat, Yangsan, South Korea

[3] Geoje Childrens Hosp, Dept Pediat, Geoje, South Korea

[4] Yonsei Univ, Coll Med, Dept Pediat, Seoul, South Korea

[5] Severance Childrens Hosp, Dept Pediat Nephrol, Seoul, South Korea

[6] Yonsei Univ, Coll Med, Seoul, South Korea

[7] Med Univ Innsbruck, Dept Internal Med Nephrol & Hypertens 4, Innsbruck, Austria

[8] Luton & Dunstable Univ Hosp NHS Fdn Trust, Luton, Beds, England

[9] Jincheon Sungmo Hosp, Dept Lab Med, Jincheon, South Korea

[10] Yonsei Univ, Coll Med, Res Inst Bacterial Resistance, Seoul, South Korea

[11] Yonsei Univ, Coll Med, Inst Kidney Dis Res, Seoul, South Korea

来源：

SCIENTIFIC REPORTS | 2017年 / 7卷

关键词：

C-REACTIVE PROTEIN; LYMPHOCYTE COUNT RATIO; DIFFERENTIAL-DIAGNOSIS; EARLY MARKER; PROCALCITONIN; MANAGEMENT; CHILDREN; PYELONEPHRITIS; BACTEREMIA; SEVERITY;

D O I：

10.1038/srep41265

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. WBC, CRP, ESR and DNI were higher in APN than in lower UTI (p < 0.01). Multiple logistic-regression analyses showed that DNI was a predictive factor for areas of lack of uptake on dimercaptosuccinic acid (DMSA) scans (P < 0.01). The area under the receiver operating characteristic (AUC) was also high for DNI (0.622, 95% CI 0.558-0.687, P < 0.01) as well as for CRP (0.731, 95% CI 0.673-0.789, P < 0.01) for the prediction of DMSA defects. DNI demonstrated the highest area under the ROC curve for diagnosis of VUR (0.620, 95% CI 0.542-0.698, P < 0.01). To the best of our knowledge, this is a first study demonstrating that DNI can be used as a diagnostic marker to distinguish APN from lower UTI and function as a diagnostic marker indicative of VUR compared to other conventional markers.

引用

页数：9

共 33 条

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