Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid

被引：10
作者：
Lu, Lu [1 ]
Zhang, Chaowen [1 ]
Li, Lihua [1 ]
Zhou, Changren [1 ]
机构：
[1] Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510630, Guangdong, Peoples R China
来源：
CARBOHYDRATE POLYMERS | 2013年 / 94卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Self-assembly; PH-responsive; Hyaluronic acid; POSS; Organic/inorganic hybrid material; POLYHEDRAL OLIGOMERIC SILSESQUIOXANE; SURFACE MODIFICATION; NANOPARTICLES; POLYMER; NANOCOMPOSITES;
D O I：
10.1016/j.carbpol.2013.01.061
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors. (C) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：444 / 448
页数：5
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