Reversible pH-responsive aggregates based on the self-assembly of functionalized POSS and hyaluronic acid

被引：10

作者：

Lu, Lu ^{[1
]}

Zhang, Chaowen ^{[1
]}

Li, Lihua ^{[1
]}

Zhou, Changren ^{[1
]}

机构：

[1] Jinan Univ, Dept Mat Sci & Engn, Guangzhou 510630, Guangdong, Peoples R China

来源：

CARBOHYDRATE POLYMERS | 2013年 / 94卷 / 01期

基金：

中国国家自然科学基金;

关键词：

Self-assembly; PH-responsive; Hyaluronic acid; POSS; Organic/inorganic hybrid material; POLYHEDRAL OLIGOMERIC SILSESQUIOXANE; SURFACE MODIFICATION; NANOPARTICLES; POLYMER; NANOCOMPOSITES;

D O I：

10.1016/j.carbpol.2013.01.061

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We report here the self-assembly of reversible pH intelligent aggregate from natural polysaccharide hyaluronic acid and functionalized polyhedral oligomeric silsesquioxane with tertiary amines and hydroxyls (POSS-AH). Various forms such as micelles, sacs and membranes were self-assembled through different procedures in this organic/inorganic hybrid system. The complex can be manipulated simply by changing pH to produce hydrogen-bond and ionic interaction. Furthermore the aggregates can form at a wide pH range by adjusting the proportion of the two constituents. These pH-responsive composites will offer potential opportunities in many fields, including cell immune barriers, drug and gene delivery systems and chemical sensors. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：444 / 448

页数：5

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